艾司西酞普兰联合无抽搐电休克治疗抑郁症的临床疗效研究

Clinical Efficacy of Escitalopram combined with Non-convulsive Electroconvulsive Therapy in the Treatment of Depression

探讨应用艾司西酞普兰联合无抽搐电休克治疗抑郁症的临床疗效.选取2022年1月-2023年1月上海市静安区精神卫生中心收治的86例抑郁症患者为研究对象,采用随机数字表法将其分为对照组和观察组两组,每组各43例,对照组接受艾司西酞普兰治疗,观察组在此基础上联合无抽搐电休克治疗,对比两组患者治疗效果.结果显示,干预后,观察组患者的HAMD-17评分低于对照组(P<0.05);干预后,观察组患者的HAMA评分低于对照组(P<0.05);观察组患者治疗总有效率高于对照组(P<0.05);干预后,观察组患者的各项实验室指标均优于对照组(P<0.05);两组患者不良反应发生情况比较,无统计学差异(P>0.05).研究发现,治疗抑郁症患者时,艾司西酞普兰联合无抽搐电休克治疗能优化治疗效果,缓解患者不良情绪,且用药安全性高.

Exploring the clinical efficacy of escitalopram combined with non-convulsive electroconvulsive therapy in the treatment of depression.86 patients with depression admitted to Shanghai Jing’an District Mental Health Center from January 2022 to January 2023 were selected as the study subjects.They were randomly divided into a control group and an observation group using a random number table method,with 43 patients in each group.The control group received escitalopram treatment,while the observation group received a combination of non-convulsive electroconvulsive therapy.The treatment effects of the two groups of patients were compared.The results showed that after intervention,the HAMD-17 score of the observation group was lower than that of the control group(P<0.05);After intervention,the HAMA score of the observation group patients was lower than that of the control group(P<0.05);The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05);After intervention,all laboratory indicators of the observation group patients were better than those of the control group(P<0.05);There was no statistically significant difference(P>0.05)in the incidence of adverse reactions between the two groups of patients.Research has found that the combination of escitalopram and non-convulsive electroconvulsive therapy can optimize the treatment effect,alleviate negative emotions in patients with depression,and have high medication safety.