慢性心力衰竭患者超声参数与脑钠肽同型半胱氨酸的相关性研究

Study on the correlation between ultrasonic parameters and brain natriuretic peptide and homocysteine in patients with chronic heart failure

目的 探究慢性心力衰竭患者超声参数与脑钠肽、同型半胱氨酸的相关性研究。方法 本研究的对象为我院2021年4月至2022年4月纳入的100例慢性心力衰竭患者,并将其作为患病组,另外选取同时期于我院参加体检的100名健康体检者作为此次研究的健康对照组。对2组心功能、左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)、N端脑钠肽前体(NT-proBNP)以及同型半胱氨酸(Hcy)水平进行检测、比较。分析数据并评估慢性心力衰竭患者Hcy与LVEDD、LVEF以及NT-proBNP的相关性。结果 相较于健康对照组,患病组患者的NT-proBNP、Hcy、LVEDD均处于更高水平(P<0.05);患病组LVEF处于更低水平(P<0.05);Ⅳ级慢性心力衰竭患者的NT-proBNP、Hcy、LVEDD水平高于Ⅲ级和Ⅱ级,而Ⅲ级NT-proBNP、Hcy、LVEDD水平高于Ⅱ级(P<0.05);Ⅳ级慢性心力衰竭患者LVEF水平低于Ⅲ级和Ⅱ级,而Ⅲ级患者LVEF水平低于Ⅱ级(P<0.05)。Pearson相关性分析结果显示,慢性心力衰竭患者中,Hcy与NT-proBNP、LVEDD呈正相关(r=0.723,0.844,P<0.05),Hcy与LVEF呈负相关(r=-0.612,P<0.05)。结论 血清NT-proBNP、Hcy、LVEDD水平随着慢性心力衰竭患者心功能恶化严重程度而逐渐升高,LVEF与之相反,即随着慢性心力衰竭患者心功能恶化严重程度而逐渐降低。

Objective To investigate the correlation between ultrasonic parameters and brain natriuretic peptide and homocysteine in patients with chronic heart failure.Methods The subjects of this study were 100 patients with chronic heart failure enrolled in our hospital from April 2021 to April 2022,and they were selected as the diseased group.In addition,100 healthy physical examination subjects who attended physical examination in our hospital at the same time were selected as the healthy control group of this study.After that,the cardiac function[left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),NT-proBNP and homocysteine(Hcy)levels]were measured and compared between the two groups.Data were analyzed and associations of Hcy with LVEDD,LVEF,and NT-proBNP were evaluated in patients with chronic heart failure.Results Compared with the healthy control group,the levels of NT-proBNP,Hcy and LVEDD in the sick group were higher(P<0.05).The level of LVEF in patients with disease was lower(P<0.05).The levels of NT-proBNP,Hcy and LVEDD in gradeⅣchronic heart failure patients were higher than those in gradeⅢand gradeⅡ,while the levels of NT-proBNP,Hcy and LVEDD in gradeⅢwere higher than those in gradeⅡ(P<0.05).The LVEF level of patients with gradeⅣchronic heart failure was lower than that of patients with gradeⅢand gradeⅡ,while the LVEF level of patients with gradeⅢwas lower than that of patients with gradeⅡ(P<0.05).The results of Pearson correlation analysis were as follows:Among various indicators in patients with chronic heart failure,Hcy showed a positive correlation with NT-proBNP and LVEDD(r=0.723,0.844,P<0.05),while Hcy showed a negative correlation with LVEF(r=-0.612,P<0.05).Conclusion Serum NT-proBNP,Hcy and LVEDD levels increased with the severity of cardiac function deterioration in patients with chronic heart failure,while LVEF levels decreased with the severity of cardiac function deterioration in patients with chronic heart failure.