小牛血去蛋白提取物眼用凝胶在角膜损伤修复中的临床效果及对干眼的影响

Clinical Effect of Deproteinized Calfblood Extract Eye Gel in Corneal Injury Repairand its Effect on Dry Eye

目的观察小牛血去蛋白提取物眼用凝胶在角膜损伤修复中的临床效果及对干眼的影响。方法选取2021年1月-2023年6月我院诊治的68例角膜损伤患者为研究对象,采用随机数字表法分为对照组和观察组,各组34例。对照组采用重组牛碱性成纤维细胞生长因子眼用凝胶治疗,观察组采用小牛血去蛋白提取物眼用凝胶治疗,比较两组临床治疗效果、角膜上皮修复时间、干眼症状评分、角膜表层上皮细胞密度和面积、眼部功能指标[角膜荧光染色评分(CFS)、泪膜破裂时间(BUT)]及临床不良反应发生情况。结果观察组治疗总有效率为94.12%,高于对照组的82.35%(P<0.05);观察组角膜上皮修复时间短于对照组,干眼症状评分低于对照组(P<0.05);两组治疗后角膜表层上皮细胞密度大于治疗前,角膜表层上皮细胞面积小于治疗前,且观察组角膜表层上皮细胞密度大于对照组,角膜表层上皮细胞面积小于对照组(P<0.05);两组治疗后CFS评分低于治疗前,BUT大于治疗前,且观察组CFS评分低于对照组,BUT大于对照组(P<0.05);观察组不良反应发生率为8.82%,与对照组的11.76%比较,差异无统计学意义(P>0.05)。结论小牛血去蛋白提取物眼用凝胶可提高角膜损伤修复效果,缩短修复时间,减轻干眼症状,改善眼部功能指标,增大角膜表层上皮细胞密度,减小角膜表层上皮细胞面积,且不良反应轻微。

Objective To observe the effect of deproteinized calfblood extract eye gel in corneal injury repair and its effect on dry eye.Methods A total of 68 patients with corneal injury diagnosed and treated in our hospital from January 2021 to June 2023 were selected as the research objects.They were divided into control group and observation group by random number table method,with 34 patients in each group.The control group was treated with recombinant bovine basic fibroblast growth factor ophthalmic gel,and the observation group was treated with deproteinized calfblood extract eye gel.The clinical treatment effect,corneal epithelial repair time,dry eye symptom score,corneal epithelial cell density and area,eye function index[corneal fluorescence staining score(CFS),tear film rupture time(BUT)]and clinical adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.12%,which was higher than 82.35%in the control group(P<0.05).The corneal epithelial repair time in the observation group was shorter than that in the control group,and the dry eye symptom score was lower than that in the control group(P<0.05).After treatment,the density of corneal epithelial cells in the two groups was higher than that before treatment,and the area of corneal epithelial cells was smaller than that before treatment,while the density of corneal epithelial cells in the observation group was higher than that in the control group,and the area of corneal epithelial cells was smaller than that in the control group(P<0.05).After treatment,the CFS score of the two groups was lower than that before treatment,and the BUT was higher than that before treatment,while the CFS score of the observation group was lower than that of the control group,and the BUT was higher than that of the control group(P<0.05).The incidence of adverse reactions in the observation group was 8.82%,which was compared with 11.76%in the control group,the difference was not statistically significant(P>0.05).Conclusion Deproteinized calfblood extract eye gel can improve the repair effect of corneal injury,shorten the repair time,reduce the symptoms of dry eye,improve the ocular function index,increase the density of corneal surface epithelial cells,and reduce the area of corneal surface epithelial cells,with mild adverse reactions.