B族维生素与偏头痛相关性研究与应用现状

Research and Application Status of Correlation Between B Vitamins and Migraine

头痛是一种原发性头痛障碍,通常表现为反复发作的中度至严重的头痛,已成为全球50岁以下患者的一个主要致残原因。偏头痛是多种遗传变异和环境危险因素共同作用的结果,B族维生素参与调节线粒体能量代谢和调节血管炎性反应。近年来研究发现B族维生素不足或缺乏(尤其是核黄素、叶酸、维生素B12)与偏头痛有关,且补充B族维生素可以改善偏头痛。本文就B族维生素与偏头痛的相关性进行综述,从而为其临床治疗提供参考。

Migraine is a primary headache disorder,usually manifested as recurrent moderate to severe headache,which has become a major cause of disability in patients under the age of 50 worldwide.Migraine is the result of a combination of genetic variations and environmental risk factors.B vitamins are involved in regulating mitochondrial energy metabolism and regulating vascular inflammatory response.In recent years,studies have found that B vitamin hypovitaminosis or B vitamin deficiency(especially riboflavin,folic acid,vitamin B12)is associated with migraine,and supplementation of B vitamins can improve migraine.This article reviews the correlation between B vitamins and migraine,so as to provide reference for its clinical treatment.