小檗碱抗皮肤癌药理作用及其机制的研究进展

Research Progress in Pharmacological Effect and Mechanism of Berberine against Skin Cancer

小檗碱是一种具有广泛药理作用的生物活性物质,除了抗炎、抗菌、抗病毒、抗腹泻、抗高血压、抗缺氧、降血糖和降血脂等作用外,还具有广谱抗肿瘤作用。该文主要从小檗碱一直皮肤癌的形成,以及抑杀皮肤黑色素瘤细胞和人皮肤鳞癌A431细胞等方面进行了综述和分析,为小檗碱在皮肤癌方面的进一步研究提供参考。

Berberine is a bioactive substance with a wide range of pharmacological effects.In addition to anti inflammatory,antibacterial,antiviral,anti-diarrhea,anti-hypertension,anti-hypoxia,hypoglycemic and hypolipidemic effects,berberine has a broad-spectrum anti-tumor effect.In this article,the effects of berberine on inhibiting the formation of skin cancer,inhibiting and killing skin melanoma cells and human cutaneous squamous cell carcinoma A431 cells,etc.are reviewed and analyzed,providing a reference for further study on berberine in skin cancer.