丹栀逍遥丸对性早熟儿童下丘脑-垂体-性腺轴激素、骨龄及睡眠质量的影响

Effects of Dangdaji Yuwan on Hypothalamic-pituitary-gonadal Axis Hormones,Bone Age and Sleep Quality in Children with Precocious Puberty

目的:观察丹栀逍遥丸对性早熟(PP)女童的下丘脑-垂体-性腺轴激素、骨龄及睡眠质量的影响,为临床降低医疗成本寻求廉验的辅助性方案。方法:选取2021年12月至2023年6月期间就诊于厦门市湖里区妇幼保健院收治的性早熟女童68例作为研究对象,按照盲法随机分为对照组和观察组,每组34例。收集患儿睡眠质量、性激素等基线资料,比较丹栀逍遥丸+曲谱瑞林治疗和单纯曲谱瑞林治疗对睡眠质量、性激素的影响。结果:通过PSQI量表评估睡眠情况,发现对比单纯曲谱瑞林治疗,丹栀逍遥丸+曲谱瑞林治疗的患儿子性早熟改善情况和睡眠质量更优,且未发现明显的不良反应发生。结论:丹栀逍遥丸对于PP女童的性早熟情况和睡眠质量有积极作用,且具有安全、低成本的特点,日后可进一步研究其作用机制。

Objective:To observe the effects of Dandajia Prowler Pill on hypothalamic-pituitary-gonadal axis hormones,bone age,and sleep quality of girls with precocious puberty(PP)and to seek an inexpensive and experimental adjunctive program to reduce the cost of medical care in the clinic.Methods:Patients attending Longyan People′s Hospital from December 2020 to June 2022 were investigated,and baseline data on sleep quality and sex hormones were collected to compare the effects of Dandejia Puanwan+Leuprorelin treatment with those of Leuprorelin treatment alone on sleep quality and sex hormones.Results:A total of 68 study subjects were included,and sleep was assessed by PSQI scale.and it was found that compared with leuprolide treatment alone,the improvement of precocious puberty and sleep quality of the patients treated with Dandeng jasmine prophylactic pill+leuprolide was superior,and no obvious adverse reactions were found to occur.Conclusion:Dangdian Yuwan has a positive effect on precocious puberty and sleep quality of PP girls,and it has the characteristics of safety and low cost.Its mechanism of action can be further investigated in the future.