沙丁胺醇结合布地奈德雾化吸入治疗儿童毛细支气管炎对患儿症状缓解时间、气道炎症反应的影响

The Effect of Salbutamol Combined with Budesonide Nebulized Inhalation Therapy on Symptom Relief Time and Airway Inflammation Response in Children with Bronchiolitis

目的 探究对儿童毛细支气管炎(简称毛支)采用沙丁胺醇结合布地奈德雾化吸入治疗的临床效果。方法 选择临川区人民医院于2022年1月至2023年7月期间诊治的86例毛支患儿用随机数字表法分为两组。两组患儿均给予控制喘息、监测病情、供氧、补液、呼吸支持等一般治疗,对照组(43例)患儿加用吸入用布地奈德混悬液,观察组(43例)患儿加用吸入用布地奈德混悬液和吸入用硫酸沙丁胺醇溶液。对比两组患儿临床症状缓解时间、气道炎症反应、肺功能、不良反应情况。结果 观察组临床症状缓解时间短于对照组(P<0.05)。治疗后,观察组白细胞介素-6(IL-6)、单核细胞趋化蛋白-1(MCP-1)水平、降钙素原(PCT)低于对照组(P<0.05);观察组用力肺活量(FVC)、第一秒用力呼气容积(FEV_(1))、γ-干扰素水平、呼气峰值流速(PEF)高于对照组(P<0.05)。两组均仅出现轻微的不良反应,组间比较无差异(P>0.05)。结论 沙丁胺醇联合布地奈德雾化吸入治疗儿童毛支能够改善患儿肺功能,降低气道炎症反应,有效缩短临床症状的缓解时间,且不良反应发生率较低。

Objective To explore the clinical effect of salbutamol combined with budesonide nebulized inhalation therapy on children with bronchiolitis.Methods 86 pediatric patients with bronchitis treated in Linchuan District People's Hospital between January 2022 to July 2023 were randomly divided into two groups using a random number table method.Both groups of children were given general treatments such as controlling wheezing,monitoring the condition,oxygen supply,fluid replacement,and respiratory support.The control group(43 cases)received budesonide suspension for inhalation,while the observation group(43 cases)received budesonide suspension for inhalation and salbutamol sulfate solution for inhalation.Comparison of clinical symptom relief time,airway inflammation response,lung function,and adverse reactions between two groups of pediatric patients.Results The clinical symptom relief time in the observation group was shorter than that in the control group(P<0.05).After treatment,the levels of interleukin-6(IL-6),monocyte chemotactic protein-1(MCP-1),and procalcitonin(PCT)in the observation group were lower than those in the control group(P<0.05);the observation group had forced vital capacity(FVC),first second forced expiratory volume(FEV_(1)),γ-interferon level and peak expiratory flow rate(PEF)were higher in the intervention group than in the control group(P<0.05).Both groups only experienced mild adverse reactions,and there was no difference between the groups(P>0.05).Conclusion The combination of salbutamol and budesonide nebulized inhalation in the treatment of pediatric bronchitis can improve lung function,reduce airway inflammation,effectively shorten the time for clinical symptom relief,and have a lower incidence of adverse reactions.