戈舍瑞林联合安宫黄体酮治疗子宫内膜异位症的效果及对血清生长因子、肿瘤标志物水平的影响

Effect of goserelin combined with medroxyprogesteron acetate in treatment of endometriosis and its impact on serum growth factor and tumor marker levels

目的探讨分析戈舍瑞林联合安宫黄体酮治疗子宫内膜异位症的效果及对血清生长因子、肿瘤标志物水平的影响。方法选择2021年6月至2023年6月乳山市中医院收治的76例子宫内膜异位症患者,随机分为对照组(安宫黄体酮)与观察组(戈舍瑞林联合安宫黄体酮)各38例,比较分析两组治疗情况。结果观察组治疗总有效率高于对照组(P<0.05);治疗后观察组黄体生成素(LH)、雌二醇(E_(2))、促卵泡激素(FSH)水平低于对照组(P<0.05);治疗后观察组血清肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶-9(MMP-9)、上皮中性粒细胞激活肽78(ENA-78)水平低于对照组(P<0.05);治疗后观察组血管内皮生长因子(VEGF)、癌胚抗原(CEA)、糖类抗原125(CA125)水平低于对照组(P<0.05)。结论戈舍瑞林联合安宫黄体酮治疗子宫内膜异位症可提高疗效,促进患者性激素、炎症指标改善,也能调节血清生长因子、肿瘤标志物水平,值得推广。

【Objective】To explore and analyze the effect of goserelin combined with medroxyprogesteron acetate on the treatment of endometriosis and its impact on serum growth factor and tumor marker levels.【Methods】Seventy-six patients with endometriosis admitted to Rushan city Hospital of Traditional Chinese Medicine from June 2021 to June 2023 were randomly divided into a control group(medroxyprogesteron acetate)and an observation group(goserelin combined with medroxyprogesteron acetate),with 38 cases in each group.The treatment outcomes of the two groups were compared and analyzed.【Results】Compared with the control group,the therapeutic effect of the observation group was significantly higher(P<0.05).After treatment,the observation group showed significantly lower levels of luteinizing hormone(LH),estradiol(E_(2)),and follicle stimulating hormone(FSH)compared with the control group(P<0.05);serum tumor necrosis factor-α(TNF-α),matrix metalloproteinase-9(MMP-9)and epithelial neutrophil activating peptide 78(ENA-78)in the observation group were significantly lower than those in the control group(P<0.05);the levels of vascular endothelial growth factor(VEGF),carcinoembryonic antigen(CEA),and carbohydrate antigen 125(CA125)were significantly lower in the observation group than in the control group(P<0.05).【Conclusion】The combination of goserelin and medroxyprogesteron acetate can improve the therapeutic effect for endometriosis,promote the improvement of sexual hormones and inflammatory indicators in patients,and also regulate the levels of serum growth factors and tumor markers.It is worth promoting.