胃镜下喷洒致康胶囊混悬液治疗肝硬化合并食管胃静脉曲张破裂出血的效果观察

Observation of therapeutic effect of Zhikang capsule suspension spraying under gastroscopy on liver cirrhosis complicated by esophagogastric variceal bleeding

目的分析胃镜下喷洒致康胶囊混悬液治疗肝硬化合并食管胃静脉曲张破裂出血的临床效果。方法队列研究。抽取2021年10月至2023年1月驻马店市中心医院收治的94例肝硬化合并食管胃静脉曲张破裂出血患者为研究对象,按随机数字表法分为致康胶囊组与聚桂醇组,每组47例。聚桂醇组采用胃镜下注射聚桂醇注射液,致康胶囊组采用胃镜下喷洒致康胶囊混悬液。比较两组疗效、输血量、再输血率。比较两组治疗前后门静脉内径(DPV)、门静脉压(PVP)、血红蛋白(Hb)、红细胞计数(RBC)、血液流变学(血浆黏度、红细胞聚集指数)。结果致康胶囊组总有效率(91.49%,43/47)与聚桂醇组(82.98%,39/47)比较差异未见统计学意义(P>0.05)。治疗后,致康胶囊组DPV、PVP低于聚桂醇组(P<0.05),Hb、RBC高于聚桂醇组(P<0.05)。致康胶囊组输血量少于聚桂醇组,再输血率低于聚桂醇组(P<0.05)。治疗后,致康胶囊组血浆黏度、红细胞聚集指数低于聚桂醇组(P<0.05)。结论胃镜下喷洒致康胶囊混悬液治疗肝硬化合并食管胃静脉曲张破裂出血可有效止血,改善血液学指标,减少输血量,降低再输血率。

Objective To analyze the clinical effect of Zhikang capsule suspension spraying under gastroscopy in the treatment of liver cirrhosis complicated by esophagogastric variceal bleeding.Methods A total of 94 patients with cirrhosis complicated by esophagogastric variceal bleeding treated in Zhumadian Central Hospital from October 2021 to January 2023 were selected as the study objects of the cohort study.And they were divided into the Zhikang capsule group and the lauromacrogol group according to random number table method,with 47 cases in each group.The lauromacrogol group was injected with lauromacrogol injection under gastroscopy,and the Zhikang capsule group was treated by Zhikang capsule suspension spraying under gastroscopy.The curative effect,blood transfusion volume and retransfusion rate were compared between the two groups.The diameter of portal vein(DPV),portal vein pressure(PVP),hemoglobin(Hb),red blood cell count(RBC),and hemorheology(plasma viscosity,erythrocyte aggregation index)were compared between the two groups before and after treatment.Results There was no significant difference in the total effective rate between the Zhikang capsule group(91.49%,43/47)and the lauromacrogol group(82.98%,39/47),P>0.05.After treatment,DPV and PVP in the Zhikang capsule group were lower than those in the lauromacrogol group(P<0.05),moreover,the levels of Hb and RBC in the Zhikang capsule group were higher than those in the lauromacrogol group(P<0.05).The Zhikang capsule group required less blood transfusion volume,and had a lower retransfusion rate compared with the lauromacrogol group(P<0.05).After treatment,the plasma viscosity and erythrocyte aggregation index in the Zhikang capsule group were lower than those in the lauromacrogol group(P<0.05).Conclusions Zhikang capsule suspension spraying under gastroscopy in the treatment of liver cirrhosis complicated by esophagogastric variceal bleeding can effectively stop bleeding,improve the hematological indexes,and reduce the amount of blood transfusion and retransfusion rate.