泪道X线造影、鱼腥草滴眼液冲洗联合泪道探通术在治疗婴幼儿泪囊炎中的应用

Application of lacrimal duct X-ray imaging,euphrasia eye drops irrigation combined with lacrimal duct probing in the treatment of infantile dacryocystitis

目的探究泪道X线造影、鱼腥草滴眼液冲洗联合泪道探通术治疗婴幼儿泪囊炎的临床疗效。方法将2021年8月至2022年8月在保定市妇幼保健院接受治疗的200例患有泪囊炎的2个月~2岁婴幼儿纳入本次研究。按照随机数字表法将其分为观察组(n=100)和对照组(n=100)。对照组患儿接受泪道X线造影+泪道探通术治疗,观察组患儿接受X线造影+鱼腥草滴眼液冲洗+泪道探通术治疗。比较2组的临床疗效、1次探通成功率、治疗前后血清炎症因子[白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)和高敏C反应蛋白(hs-CRP)]水平、并发症发生情况及术后复发情况。结果观察组患儿的总有效率为92.00%,显著高于对照组(81.00%),差异有统计学意义(P<0.05)。观察组的1次探通成功率为94.00%,显著高于对照组(85.00%),差异有统计学意义(P<0.05)。治疗后,2组的血清IL-6、TNF-α和hs-CRP水平均较治疗前显著下降,且观察组治疗后的血清IL-6、TNF-α和hs-CRP水平分别为(2.49±0.77)pg/mL、(5.13±1.60)pg/mL、(10.63±2.39)mg/L,均显著低于对照组[(3.65±0.89)pg/mL、(6.01±1.75)pg/mL、(13.17±2.71)mg/L],差异均有统计学意义(P<0.05)。2组的总并发症发生率和复发率比较,差异均无统计学意义(P>0.05)。结论泪道X线造影+鱼腥草滴眼液冲洗+泪道探通术治疗婴幼儿泪囊炎的临床疗效良好,可显著提高1次探通成功率,降低炎症反应,且安全性良好,术后不易复发。

Objective To explore the clinical effectiveness of lacrimal duct X-ray imaging,euphrasia eye drops irrigation combined with lacrimal duct probing in the treatment of infantile dacryocystitis.Methods Two hundreds infants aged 2 months to 2 years with dacryocystitis who received treatment at Baoding Maternal and Child Health Hospital from August 2021 to August 2022 were included in this study.According to the random number table method,they were divided into the observation group(n=100)and the control group(n=100).The control group received lacrimal duct X-ray imaging+lacrimal duct probing treatment,while the observation group received X-ray imaging+euphrasia eye drops irrigation+lacrimal duct probing treatment.The clinical effectiveness,success rate of the first probing,serum inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α)]levels,and high-sensitivity C-reactive protein(hs-CRP),occurrence of complications,and postoperative recurrence were compared.Results The total effective rate of the observation group was 92.00%,which was significantly higher than that of the control group(81.00%),and the difference was statistically significant(P<0.05).The one-time success rate of the observation group was 94.00%,which was significantly higher than that of the control group(85.00%),and the difference was statistically significant(P<0.05).After treatment,the levels of serum IL-6,TNF-α,and hs-CRP in two groups were lower those before treatment,and the levels of serum IL-6,TNF-α,and hs-CRP in the observation group after treatment were(2.49±0.77)pg/mL,(5.13±1.60)pg/mL,and(10.63±2.39)mg/L,respectively,which were significantly lower than those of the control group[(3.65±0.89)pg/mL,(6.01±1.75)pg/mL,and(13.17±2.71)mg/L],and the differences were statistically significant(P<0.05).There were no statistically significant difference in the total incidence of complications and recurrence rates between the two groups(P>0.05).Conclusion Lacrimal duct X-ray imaging,euphrasia eye drops irrigation combined with lacrimal duct probing have good clinical effectiveness in the treatment of infantile dacryocystitis.It can significantly improve the success rate of the first probing,reduce inflammation,and has good safety with a low risk of postoperative recurrence.