中药崖柏化学成分、药理作用及其应用前景研究

Chemical constituents,pharmacological action and application prospect of thuja sutchuenensis

崖柏为珍稀物种,其根、叶、花等部位含有多种活性成分,在替代药物及保健食品开发中极具价值。本文通过对崖柏的专利及论文搜索平台统计整理,综合分析了崖柏的挥发油、树脂、木质素、黄酮类、多糖类等5大类主要化学成分;对崖柏的抗菌作用、抗炎作用、抗氧化作用、抗肿瘤、抗虫、抗辐射药理作用以及毒性和安全性情况进行了总结;梳理了已上市的崖柏产品相关情况;探讨限制崖柏发展的因素包括产品同质化严重,制剂工艺粗糙、剂型单一,产学研合作不足,主产区种植和产量极少的问题;提出了崖柏未来发展前景,并提出3点发展的建议,即开发崖柏各部位的保健与营养价值,扩充适合崖柏的剂型和产品,加强政策支持力度,深化产学研合作,为我国崖柏药品及保健食品的产业发展提供新思路。

Thuja sutchuenensis is a rare species.Its roots,leaves,flowers and other parts contain many active ingredients,which is of great value in the development of alternative medicine and health food.Based on the statistics of patent and paper search platform,5 main chemical components of thuja sutchuenensis are analyzed comprehensively,including volatile oil,resin,lignin,flavonoid and polysaccharide.The effects of antibacterial,anti-inflammatory,antioxidant,anti-tumor,anti-insect,anti-radiation,toxicity and safety of thuja sutchuenensis are summarized.The related situation of listed huja sutchuenensis products is reviewed.The factors restricting the development of thuja sutchuenensis include serious product homogeneity,rough preparation process,single dosage form,insufficient cooperation between production,university and research,and few planting and production in main producing areas.The future development prospect of thuja sutchuenensis is put forward,and 3 development suggestions are put forward,namely,developing the health and nutrition value of each part of thuja sutchuenensis,expanding the dosage forms and products suitable for thuja sutchuenensis,strengthening the policy support,deepening the cooperation between industry,university and research,providing new ideas for the industrial development of thuja sutchuenensis and health-care food in China.