妊娠期高血压疾病合并妊娠期糖尿病产妇的临床特征及妊娠结局分析

Analysis of clinical features and pregnancy outcomes of pregnant women with hypertensive disorders of pregnancy complicated with gestational diabetes mellitus

目的探讨妊娠期高血压疾病(HDP)合并妊娠期糖尿病(GDM)产妇的临床特征及妊娠结局。方法回顾性分析4088例GDM产妇的临床资料。根据是否合并HDP分为合并组(GH组,252例)和GDM组(3836例),对比两组产妇的临床特征和妊娠结局。结果与GDM组比较,GH组的年龄更高、分娩孕周更小,剖宫产率、合并胆汁淤积症率、合并甲状腺功能减退症率及胎盘早剥发生率均更高(P<0.05);胎儿窘迫、胎儿生长受限、低出生体重和早产发生率均更高,且新生儿出生体重和出生身长均更低(P<0.05)。结论GDM合并HDP产妇的不良妊娠结局显著升高,临床应重视对合并GDM及HDP孕产妇的早期干预,以防止不良妊娠结局发生。

Objective To investigate the clinical features and pregnancy outcomes of pregnant women with hypertensive disorders of pregnancy(HDP)complicated with gestational diabetes mellitus(GDM).Methods The clinical data of 4088 women with GDM were analyzed retrospectively.They were divided into the GH group(252 cases)and the GDM group(3836 cases)according to whether HDP was combined,and the clinical characteristics and pregnancy outcomes of the two groups were compared.Results Compared with GDM group,GH group had higher age,smaller gestational week,higher cesarean section rate,higher incidences of cholestasis and hypothyroidism,higher incidence of placental abruption(P<0.05);and had higher incidences of fetal distress,fetal growth restriction,low birth weight and premature delivery,and lower birth weight and birth length of newborns(P<0.05).Conclusion The adverse pregnancy outcome of women with GDM combined with HDP is significantly increased.Clinical attention should be paid to early intervention of women with GDM combined with HDP to reduce the occurrence of adverse pregnancy outcome.