重组干扰素α-2b联合CO_(2)激光气化治疗宫颈低级别上皮内病变伴HR-HPV感染患者的临床效果及对HPV转阴率的影响

The clinical effect of recombinant interferon α-2b combined with CO_(2)laser gasification in the treatment of cervical low-grade intraepithelial lesions with HR-HPV infection and its impact on HPV negative conversion rate

目的分析重组干扰素α-2b联合CO_(2)激光气化治疗宫颈低级别上皮内病变伴高危型人乳头瘤病毒(HR-HPV)感染的临床效果。方法选取宫颈低级别上皮内病变伴HR-HPV感染患者80例,采用随机数表法分为对照组及研究组,每组40例。对照组采用重组干扰素α-2b治疗,研究组采用重组干扰素α-2b联合CO_(2)激光气化治疗。比较两组患者的治疗效果。结果研究组治疗总有效率为90.00%,高于对照组的72.50%(P<0.05)。研究组治疗3、6个月的HPV转阴率均高于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论采用重组干扰素α-2b联合CO_(2)激光气化治疗宫颈低级别上皮内病变伴HR-HPV感染患者,可提高疗效及HPV转阴率。

Objective To analyze the clinical effect of recombinant interferon α-2b combined with CO_(2)laser gasification in the treatment of cervical low-grade intraepithelial lesions with high-risk human papillomavirus(HR-HPV)infection.Methods 80 patients with cervical low-grade intraepithelial lesions with HR-HPV infection were selected and were divided into a control group and a study group by random number table method,with 40 cases in each group.The control group was treated with recombinant interferon α-2b,and the study group was treated with recombinant interferon α-2b combined with CO_(2) laser gasification.The therapeutic effects of the two groups were compared.Results The total effective rate of the study group was 90.00%,which was higher than 72.50% of the control group(P<0.05).The HPV negative conversion rate in the study group were higher than those in the control group at 3 and 6 months after treatment(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Recombinant interferon α-2b combined with CO_(2) laser gasification in the treatment of cervical low-grade intraepithelial lesions with HR-HPV infection can improve the curative effect and HPV negative conversion rate.