氢解脱苄反应钯基合金催化剂研究进展

Research progress on Pd-based alloy catalysts for hydrogenolysis debenzylation reaction

氢解脱苄反应是有机合成较为关键的一步工艺。然而,贵金属钯(Pd)的使用以及使用过程中不可避免的流失,极大地增加了产品的成本。为此,开发高性能、长寿命、低成本氢解催化剂成为提升产品竞争力的核心技术。其中,Pd基合金催化剂由于协同效应、高稳定性和非贵金属部分替代而成为更具发展潜力的策略。因此,从氢解脱苄催化反应机理入手,综述近年来氢解脱苄反应Pd基合金催化剂取得的研究进展,讨论Pd基合金催化剂的设计原则、制备方法和合金效应,结合工业化氢解脱苄反应的特征,对Pd基合金催化剂的设计、制备、应用、回收作出总结和展望。

Hydrogenolysis debenzylation reaction is considered as a key process in organic synthesis field.However,the use of precious Pd metal and its inevitable loss greatly increase the cost of product.Therefore,developing hydrogenolysis catalysts with high performance,long life and low cost is regarded as the core technology to improve the product competitiveness.Among various alternative strategies,Pd-based alloy catalysts becomes a more potential scheme due to the synergistic effect,better stability and partial substitution with non-noble metals.Herein,this review summarizes recent progress of Pd-based alloy catalysts for hydrogenolysis debenzylation reaction based on the mechanism,then discusses the design principle,preparation method and alloy effect of Pd-based alloy catalysts.Finally,the design,preparation,application and recycle of Pd-based alloy catalysts are summarized and given an outlook from the perspective of industrialized hydrogenolysis debenzylation reaction.