头皮控油平衡复合酸改善头皮脂溢性皮炎的疗效与安全性研究

A study on the efficacy and safety of a scalp oil-balancing compound acid for scalp seborrheic dermatitis

目的研究头皮控油平衡复合酸在改善头皮脂溢性皮炎(SSD)中的疗效与安全性。方法招募50例符合纳入条件的SSD患者作为受试者,在入组当日对其头皮进行第1次刷酸,后续再进行3次,共4次,刷酸间隔时间为1周。每次刷酸前对受试者进行症状评分,最后1次刷酸2周后进行随访。采用皮肤镜分别对斑丘疹、油腻、红斑、头屑等临床症状进行评分,真菌荧光检测马拉色菌情况,通过受试者主观评分问卷对头皮瘙痒及头皮痛进行评价。结果试验过程中退组3例,实际纳入分析47例。使用头皮控油平衡复合酸治疗结束后2周,受试者斑丘疹评分从2.09±1.25降至0.13±0.34,油腻评分从3.19±0.77降至0.87±0.65,红斑评分从3.23±0.63降至0.43±0.68,头屑评分从3.26±0.94降至0.55±0.65,各症状评分均有明显改善,差异均有统计学意义(均P<0.01)。95.74%患者马拉色菌阳性转为阴性。头皮瘙痒及头皮痛程度主观评分分别从3.21±0.75、1.70±1.27下降至0.57±0.58、0.50±0.60,差异均有统计学意义(均P<0.01)。治疗中未出现不良反应。结论头皮控油平衡复合酸在改善SSD头皮瘙痒、斑丘疹、油腻、头屑、头皮痛及清除马拉色菌等方面临床疗效较好,且具有较高的安全性。

Objective To investigate the efficacy and safety of a Compound Acid in improving seborrheic dermatitis of the scalp.Methods Fifty patients with seborrheic dermatitis who met the inclusion criteria were enrolled.The subjects underwent scalp brushing with Compound Acid for a total of four brushings,with the first acid brushing on the day of enrollment and subsequent brushings at one-week interval.Symptom scores were assessed before each acid brushing.A follow-up examination was conducted two weeks after the last acid brushing.Clinical signs and symptoms such as papules,greasiness,erythema,and dandruff were scored using skin microscopy.The status of Malassezia infection was detected using fungus fluorescent microscope.A questionnaire was used to evaluate subjects′scalp itching and pain.Results Forty-seven subjects completed this study.Following the use of the Compound Acid,subjects showed significant improvements in maculopapule scores(from 2.09±1.25 to 0.13±0.34),greasiness scores(from 3.19±0.77 to 0.87±0.65),erythema scores(from 3.23±0.63 to 0.43±0.68),and dandruff scores(from 3.26±0.94 to 0.55±0.65)(all P<0.01).In 95.74%of patients,Malassezia was changed from positive to negative.Subjective scores for scalp itching and pain were improved from 3.21±0.75 to 0.57±0.58 and from 1.70±1.27 to 0.50±0.60,respectively(both P<0.01).No adverse reactions were reported throughout the study.Conclusion The compound acid is effective and safe for seborrheic dermatitis,including improvements in scalp itching,maculopapules,greasiness,dandruff and scalp pain.