射血分数保留型心力衰竭临床诊断及治疗的研究进展

Progress in the clinical diagnosis and therapy of heart failure with preserved ejection fraction

射血分数保留型心力衰竭(HFpEF)的病死率较高且发病率不断增加,可能成为未来心力衰竭的主要类型,是心血管疾病中的重要问题。尽管近年HFpEF的研究取得了一些重要进展,但其发病机制仍未完全清楚,患者的预后及病死率并未得到明显改善。由于HFpEF合并症较多、病理机制复杂、传统心力衰竭治疗药物不能有效改善HFpEF患者的预后,目前仍缺乏精准的诊断方法和有效的临床治疗策略。探索和开发有效的诊断及治疗方法具有重要的临床意义。本文就近年来HFpEF诊断和治疗方面取得的研究进展及未来研究方向作一综述。

Heart failure with preserved ejection fraction(HFpEF)may be a main form of heart failure,with a high mortality and an increasing incidence,which is a significant problem in cardiovascular disease.Although some important advancements in HFpEF has been made in recent years,its pathogenesis remains unclear,and the prognosis and mortality of patients have not significantly improved.Due to a large number of complications and complex pathological mechanism of HFpEF,and traditional treatment medicines of heart failure cannot effectively improve the prognosis of HFpEF patients,it is still lack of accurate diagnostic methods and effective clinical treatment strategies.Exploring and developing effective diagnostic and therapeutic approaches are of great clinical significance.This review summarizes the progress and future research direction in the diagnosis and treatment of HFpEF.