针刺结合中药保留灌肠对溃疡性结肠炎的疗效及免疫功能的影响

Therapeutic Effects of Acupuncture Combined with Retention Enema of Chinese Herbal Medicine on Ulcerative Colitis and its Impact on Immune Function

目的:探讨针刺结合中药保留灌肠治疗溃疡性结肠炎(UC)的临床疗效及其改善免疫功能的作用。方法:选取符合纳入标准的UC患者70例,依据随机数字表随机分为观察组和对照组,各35例。对照组给予美沙拉嗪缓释片,观察组在对照组基础上加用针刺与中药保留灌肠疗法,两组均治疗8周。比较两组患者治疗前后血清免疫功能指标CD3^(+)、CD4^(+)与CD8^(+)含量、炎症因子指标白细胞介素(IL)-1β、IL-23与转化生长因子-β1(TGF-β1)的改善情况。结果:治疗后,两组患者TGF-β1、CD3^(+)、CD4^(+)含量均较治疗前明显升高(P<0.05),IL-1β、IL-23、CD8^(+)含量下降(P<0.05);且观察组治疗后TGF-β1、CD3^(+)和CD4^(+)水平均高于对照组(P<0.05),IL-1β、IL-23、CD8^(+)水平均低于对照组(P<0.05)。结论:针刺结合中药保留灌肠治疗能显著改善UC患者免疫功能,降低其炎症因子水平。

Objective:To explore the clinical efficacy of acupuncture combined with retention enema of Chinese herbal medicine in the treatment of ulcerative colitis(UC)and its impact on improving immune function.Methods:A total of 70 UC patients meeting the inclusion criteria were randomly divided into the observation group and the control group,with 35 cases in each group.The control group was treated with mesalazine sustained-release tablets,while the observation group received additional acupuncture and TCM retention enema on top of the control treatment.Both groups were treated for 8 weeks.The levels of immune function indicators(CD3^(+),CD4^(+),and CD8^(+))and inflammatory cytokines(IL-1β,IL-23,and TGF-β1)were compared before and after treatment.Results:After treatment,the levels of TGF-β1,CD3^(+),and CD4^(+)significantly increased(P<0.05),while the levels of IL-1β,IL-23,and CD8^(+)decreased in both groups(P<0.05).Furthermore,the observation group showed significantly higher levels of TGF-β1,CD3^(+),and CD4^(+)and lower levels of IL-1β,IL-23,and CD8^(+)compared to the control group(P<0.05).Conclusion:Acupuncture combined with Chinese herbal medicine retention enema can significantly improve immune function and reduce inflammation in UC patients.