长链非编码RNA SNHG16在消化系统肿瘤中作用机制研究进展

Advances in understanding of mechanism of long non-coding RNA SNHG16 in digestive system tumors

长链非编码RNA小核仁RNA宿主基因16(long non-coding RNA small nucleolar RNA host gene 16,LncRNA SNHG16),是小核仁RNA宿主基因家族的成员,主要位于细胞质中.研究表明SNHG16在前列腺癌、乳腺癌、膀胱癌、胃癌、结肠癌等多种恶性肿瘤中异常高表达.通过多种途径调控肿瘤细胞增殖、侵袭、迁移和凋亡等.本文主要总结了SNHG16在消化系统恶性肿瘤中的作用,包括SNHG16的异常表达、分子功能、调控网络以及相关临床特征,为肿瘤的早期诊断和早期治疗提供新思路.

The long non-coding RNA small nucleolar RNA host gene 16(SNHG16),a member of the small nucleolar RNA host gene family,is mainly located in the cytoplasm.Studies have showed that SNHG16 is abnormally highly expressed in prostate cancer,breast cancer,bladder cancer,stomach cancer,colon cancer,and other malignant tumors.It influ-ences the proliferation,invasion,migration,and apoptosis of tumor cells through various mechanisms.In this paper,we summarize the role of SNHG16 in digestive system malignant tumors,including its abnormal expression,molecular function,regulatory network,and related clinical features,with an aim to provide new ideas for early diagnosis and early treatment of tumors.