四联疗法联合益生菌治疗对幽门螺杆菌阳性胃溃疡患儿的临床疗效及其对炎症因子的影响

Quadruple therapy combined with probiotics for treatment of children with Helicobacter pylori-positive gastric ulcer:Efficacy and influence on inflammatory factors

背景微生态疗法可通过扶植正常菌群调节机体内的菌群平衡、稳定胃肠道微生态系统.因此本研究在常规四联疗法的基础上加用益生菌,认为二者联用对幽门螺旋杆菌阳性胃溃疡患儿可能会表现出更好的临床疗效.目的探究四联疗法联合益生菌治疗对幽门螺杆菌(Helicobacter pylori,H.pylori)阳性胃溃疡患儿的临床疗效及其对炎症因子的影响.方法纳入2021-01/2022-01在我院就诊的100例H.pylori阳性胃溃疡患儿作为研究对象,根据治疗方式将其分为对照组(n=50)和观察组(n=50).对照组给予常规四联疗法(胶体果胶铋胶囊、雷贝拉唑、克拉霉素、阿莫西林联用),观察组在对照组的基础上给予培菲康散剂治疗.统计两组患儿临床资料并比较其临床疗效,并比较治疗前后两组患儿临床症状评分、H.pylori根除率、溃疡愈合率、血清炎性因子水平及安全性分析结果.结果治疗后,观察组临床疗效显著高于对照组(P<0.05).两组患儿临床症状评分、H.pylori根除率、溃疡愈合率及肿瘤坏死因子-α、白细胞介素-1、白细胞介素-6水平显著降低(P<0.05),且观察组显著低于对照组(P<0.05).两组患儿胃肠道不适、皮疹、呕吐比较差异无统计学意义.结论四联疗法联合益生菌治疗对H.pylori阳性胃溃疡患儿具有显著疗效,可提高患儿H.pylori根除率及溃疡愈合率,降低患儿体内炎症因子水平,且安全性良好.

BACKGROUND Microecological therapy can regulate the balance of flora in the body and stabilize the gastrointestinal microecosystem by fostering normal flora.It was believed that the combi-nation of probiotics and conventional quadruple therapy may show better clinical efficacy in children with Helicobacter pylori(H.pylori)-positive gastric ulcer.AIM To investigate the clinical efficacy of quadruple therapy combined with probiotics in children with H.pylori-positive gastric ulcer and the effect on inflammatory factors.METHODS One hundred children with H.pylori-positive gastric ulcer treated at our hospital from January 2021 to January 2022 were selected as the research subjects.They were divided into either a control group(n=50)or an observation group(n=50)using the random number table method.Both groups were given convetntional quadruple therapy(Colloidal Bismuth Pectin Capsules,Rabeprazole,Clarithromycin,and Amoxicillin),and the observation group was additionally given Bifico Powder.The clinical data of the two groups were collected and the clinical efficacy was compared.The clinical symptom score,H.pylori eradication rate,ulcer healing rate,serum inflammatory factor levels,and safety were also compared between the two groups before and after treatment.RESULTS The clinical efficacy in the observation group was signifi-cantly higher than that in the control group(P<0.05).The clinical symptom scores,H.pylori eradication rate,ulcer healing rate,and tumor necrosis factor-α,interleukin-1,and interleukin-6 levels in both groups were significantly decreased after treatment(P<0.05),and these indexes in the observation group were significantly better than those in the control group(P<0.05).There was no significant difference in gastrointestinal discomfort,rash,or vomiting between the two groups.CONCLUSION Quadruple therapy combined with probiotics has significant clinical effects in children with H.pylori-positive gastric ulcer,and can improve the eradication rate of H.pylori and healing rate of ulcer and reduce the levels of inflammatory factors with good safety.