脓毒症ICU获得性衰弱发病机制及诊疗研究进展

Research advance in pathogenesis and diagnosis and treatment of sepsis ICU-AW

ICU获得性衰弱(intensive care unit acquired weakness,ICU-AW)作为重症监护室脓毒症患者的常见并发症,多累及骨骼肌、呼吸肌及平滑肌等,会导致脱机困难、住院时间延长、医疗费用剧增,并严重影响患者远期生活质量。但脓毒症ICU-AW的发病机制尚不明确、诊断评估标准缺乏统一、治疗时机和方案选择仍无具体标准。鉴于该病发病机制和诊疗选择存在争议,本文结合国内外文献资料,对脓毒症患者ICU-AW的发病机制及诊疗措施相关研究进展进行综述,以期加深临床多学科对该病的认知并针对性提高疾病的早期认识、诊断及诊疗协作能力。

Intensive care unit acquired weakness(ICU-AW),as a common complication of patients with sepsis in intensive care unit,mostly involves skeletal muscle,respiratory muscle and smooth muscle,which will lead to difficulty in weaning from mechanical ventilation,prolonged hospital stay,sharp increase in medical costs,and seriously affect the long-term quality of life of patients.However,the pathogenesis of sepsis ICU-AW is still unclear,the diagnostic and evaluation criteria are lack of unity,and there is still no specific standard for the choice of treatment timing and regimen.In view of the controversy about the pathogenesis,diagnosis and treatment of this disease,this article reviews the research progress on the pathogenesis,diagnosis and treatment of ICU-AW in patients with sepsis based on domestic and foreign literature,in order to deepen the clinical multidisciplinary understanding of this disease and improve the early recognition,diagnosis and treatment collaboration ability.