孤独症谱系障碍与肠道菌群干预的研究进展

Advances in autism spectrum disorder and gut microbiota intervention

孤独症谱系障碍(autism spectrum disorder,ASD)是一组以社会沟通和社会互动障碍以及重复刻板行为为主要症状的神经发育障碍性疾病, 其病因尚不明确。目前, 国内外研究均显示, 肠道菌群失调在ASD中普遍存在, 重塑肠道菌群成为ASD治疗的热点。相关的干预方法主要包括益生菌、益生元和菌群移植。然而, 其对ASD的有益作用仍然有限且尚未明确, 未来仍需要进行更多、更大规模的深入研究来探索最佳治疗方案。该文综述了ASD患儿肠道菌群的变化以及肠道菌群干预的研究进展, 旨在为ASD早期诊断和治疗干预提供新思路。

Autism spectrum disorder(ASD)is a group of neurodevelopmental disorders characterized by social communication and interaction disorders,as well as repetitive stereotyped behaviors,with unclear etiology.At present,domestic and foreign studies have shown that gut microbiota imbalance is commonly present in ASD,and reshaping the gut microbiota has become a hot topic in the treatment of ASD.The relevant intervention methods mainly include probiotics,prebiotics,and microbiota transplantation.However,its beneficial effects on ASD are still limited and uncertain,and more large-scale and in-depth research is still needed in the future to explore the optimal treatment options.This article reviews the changes in gut microbiota in children with ASD and the research progress on gut microbiota intervention,aiming to provide new ideas for early diagnosis and treatment intervention of ASD.