非甾体抗炎药加重呼吸道疾病诊断和治疗专家共识(2024,成都)

Expert consensus on the diagnosis and treatment of respiratory diseases exacerbated by nonsteroidal anti-inflammatory drugs(2024,Chengdu)

非甾体抗炎药加重呼吸道疾病(non-steroidal anti-inflammatory drugs-exacerbated respiratory disease,N-ERD)是一种慢性呼吸道嗜酸性炎症性疾病,其特征为慢性鼻窦炎(chronic rhinosinusitis,CRS)、哮喘以及对环氧化酶-1(cyclooxygenase 1,COX-1)抑制剂不耐受,使用此类药物后,患者出现鼻炎、哮喘症状急性加重的综合征。N-ERD在我国尚未引起足够重视,临床中漏诊比例较高,相关研究较缺乏。有鉴于此,中国鼻病研究协作组召集了国内鼻科学界的一线青年专家,结合国内外最新的循证医学依据,制订了本共识,共识包括疾病的流行病学、发病机制、临床表现、诊断方法以及治疗策略,包括药物治疗、手术、生物制剂治疗及脱敏治疗等方面。旨在提高对N-ERD的认识,减少漏诊,并提高治疗效果。

Non-steroidal anti-inflammatory drugs-exacerbated respiratory disease(N-ERD)is a chronic respiratory disease characterized by eosinophilic inflammation,featuring chronic rhinosinusitis(CRS),asthma,and intolerance to cyclooxygenase 1(COX-1)inhibitors.The use of these medications can lead to an acute worsening of rhinitis and asthma symptoms.This condition has not yet received sufficient attention in China,with a high rate of misdiagnosis and a lack of related research.The Chinese Rhinology Research Group convened a group of leading young experts in otolaryngology from across the country,based on the latest domestic and international evidence-based medical practices to formulate this consensus.The consensus covers the epidemiology,pathogenesis,clinical manifestations,diagnostic methods,and treatment strategies for N-ERD,including pharmacotherapy,surgery,biologic treatments,and desensitization therapy.The goal is to improve recognition of N-ERD,reduce misdiagnosis,and enhance treatment outcomes.