基于转录组测序的变应性鼻炎研究进展

Progress of allergic rhinitis research based on transcriptome sequencing

目的:传统研究变应性鼻炎(allergic rhinitis,AR)主要通过动物模型和分子生物学方法研究,转录组测序技术的诞生推进了AR基因层面的探索。近年来重点聚焦于常见RNA在AR中作用的研究,提示AR的生物信息学分析已取得突破性进展。本文拟综述AR研究进展、转录组测序技术的发展、转录组测序在AR中的应用等,以期为临床挖掘AR潜在的药物靶点,为精准治疗提供参考。

Traditional studies on allergic rhinitis(AR)have mainly adopted animal models and biomolecular approaches.In addition,the advent of transcriptome sequencing technology is promoting the development of AR at the genetic level.Recently,many scholars have focused on the role of common RNA in the pathogenesis of AR,suggesting that breakthroughs have been made in the field of AR bioinformatics analysis.This review aims to summarize the research advances in AR,the development of transcriptome sequencing technology,and the application of transcriptome sequencing in AR,in order to explore potential drug targets for AR treatment and provide new insights into precision medicine.