右旋糖酐铁口服液联合维生素C对缺铁性贫血患儿血清铁蛋白含量的影响

Effect of dextran iron oral liquid combined with vitamin C on serum ferritin content in children with iron deficiency anemia

目的分析右旋糖酐铁口服液联合维生素C对缺铁性贫血(IDA)患儿血清铁蛋白含量的影响。方法选取2019年9月至2022年4月郑州大学附属儿童医院收治的120例IDA患儿为研究对象,按照随机数字表法分为常规组与观察组,每组60例。常规组予以右旋糖酐铁口服液,观察组在常规组基础上联合维生素C。比较两组疗效、血常规[红细胞计数(RBC)、血红蛋白(Hb)、血清铁(SI)、血清铁蛋白(SF)]水平、平均红细胞容积(MCV)、平均血红蛋白浓度(MCHC)水平及不良反应。结果观察组治疗总有效率为95.00%(57/60),常规组为80.00%(48/60),差异有统计学意义(P<0.05)。观察组贫血纠正时间短于常规组,差异有统计学意义(P<0.05)。治疗后,观察组RBC、Hb、SI、SF水平高于常规组,MCV、MCHC水平高于常规组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异未见统计学意义(P>0.05)。结论右旋糖酐铁口服液联合维生素C治疗IDA患儿效果确切,可改善血常规指标,减轻贫血症状,且具有安全性。

Objective To analyze the effects of dextran iron oral liquid combined with vitamin C on serum ferritin content in children with iron deficiency anemia(IDA).Methods One hundred and twenty children with IDA in Zhengzhou University Affiliated Children’s Hospital from September 2019 to April 2022 were selected and randomly divided into an observation group and a conventional group,with 60 cases in each group.The conventional group was given iron dextran oral solution,while the observation group received a combination of vitamin C on the basis of the conventional group.The therapeutic effects,blood routine[red blood cell count(RBC),hemoglobin(Hb),serum iron(SI),serum ferritin(SF)]levels,mean corpuscular volume(MCV),mean hemoglobin concentration(MCHC)levels,and adverse reactions between the two groups were compared.Results The total effective rate of treatment in the observation group was 95.00%(57/60),which was higher than that in the conventional group[80.00%(48/60)](P<0.05).The correction time for anemia in the observation group was shorter than that in the conventional group(P<0.05).After treatment,the levels of RBC,Hb,SI,and SF in the observation group were higher than those in the conventional group(P<0.05).After treatment,the levels of MCV and MCHC in the observation group were higher than those in the conventional group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions The combination of iron dextran oral solution and vitamin C has a definite effect on children with IDA,which can improve the blood routine indicators,alleviate anemia symptoms,and is safe.