具有杀菌和除草活性的异噁唑类化合物研究进展

Research progress of isoxazole compounds with fungicidal and herbicidal activities

含氮杂环广泛存在于天然产物和药物分子中,在药物开发领域扮演着重要角色。异噁唑作为含氮杂环中重要一员,具有广阔的应用前景。异噁唑及其衍生物是重要的有机合成子,具有良好的杀菌、除草、杀虫等生物活性。对2017年以来报道的具有杀菌和除草活性的异噁唑类化合物及其合成路线进行了综述,并概括了各类化合物对不同病原菌、杂草的防治效果,简要分析了不同结构与生物活性之间的关系,以期为异噁唑类农药的研究开发提供参考。

Nitrogen-containing heterocycles,pivotal in drug development,are prevalent in both natural products and pharmaceutical compounds.Among these,isoxazole stands out as a promising candidate.Isoxazole and its derivatives serve as important organic synthons,boasting enhanced fungicidal,herbicidal,insecticidal,and other bioactive properties.This review focuses on isoxazoles exhibiting fungicidal and herbicidal activities,along with their synthesis routes reported since 2017.We comprehensively outlined the efficacy of analogues against various pathogens and weeds and briefly examines the correlation between structural variations and biological activities.This review offers insights into the advancement of isoxazole-based pesticides.