北京市某社区男性迟发性性腺功能减退的关联因素分析

Correlation analysis of late-onset hypogonadism in a community in Beijing

目的探讨男性迟发性性腺功能减退的关联因素。方法该研究为横断面研究。纳入2023年2月6日至6月30日在北京市海淀区羊坊店社区卫生服务中心参加健康体检的40~75岁男性居民,筛选出迟发性性腺功能减退(LOH)的患者作为LOH组,并按年龄匹配对照组。收集入选者的一般临床资料。抽取入选者空腹静脉血,完善一般健康体检项目的同时测定总睾酮、性激素结合球蛋白水平,并计算游离睾酮水平。通过汉化的老年男性症状量表(AMS)评定相关症状。采用多因素logistic回归模型分析LOH的关联因素。结果满足入排标准并获得知情同意的社区男性居民共233人,其中诊断为LOH者42例(18.03%)。按年龄进行匹配,LOH组和对照组各入选40人,年龄分别为(64.8±6.0)和(62.3±8.6)岁。多因素logistic回归分析结果显示,糖尿病和血脂异常与LOH呈独立正向关联(分别为OR=4.497,95%CI:1.291~15.664,P=0.018;OR=8.431,95%CI:1.566~45.405,P=0.013),而血红蛋白水平与LOH呈独立负向关联(OR=0.923,95%CI:0.874~0.975,P=0.004)。结论血脂异常、糖尿病与LOH呈独立正向关联,血红蛋白水平与LOH呈独立负向关联。

Objective To investigate the factors associated with late-onset hypogonadism(LOH)in men.Methods This was a cross-sectional study.Male residents aged 40-75 years who attended health examinations at the Yangfangdian Community Health Service Center in Haidian District,Beijing from February 6th to June 30th,2023 were included.The LOH group was selected based on diagnostic criteria and matched to the control group according to age.General clinical data were collected from both groups,fasting venous blood samples were taken and general health examination items were completed.Total testosterone(TT)and sex hormone-binding globulin(SHBG)levels were measured,and free testosterone(fT)were calculated.Relevant symptoms were assessed using the Chinese version of the Aging Males′Symptoms(AMS)scale.Single and multiple factor comparative analyses were conducted to explore the factors related to LOH.Results A total of 233 male residents from the community who met the inclusion criteria and gave informed consent were included,of whom 42 cases(18.03%)were diagnosed with LOH.After age matching,the final LOH and control groups consisted of 40 individuals each((64.8±6.0)years vs.(62.3±8.6)years,P>0.05).There were statistically significant differences between the LOH and control groups for body mass index,waist circumference,sex hormone-binding globulin,AMS scores,and hemoglobin.The prevalence of diabetes and dyslipidemia was significantly higher in the LOH group than in the control group(both P<0.05).Multivariate logistic regression analysis showed that diabetes(OR=4.497,95%CI:1.291-15.664,P=0.018),dyslipidemia(OR=8.431,95%CI:1.566-45.405,P=0.013),and hemoglobin level(OR=0.923,95%CI:0.874-0.975,P=0.004)were significantly associated with LOH.Conclusion Diabetes,dyslipidemia and hemoglobin levels are significantly associated with LOH.