炎症性肠病与阿尔茨海默病共病的研究进展

Comorbidity between inflammatory bowel disease and Alzheimer disease

炎症性肠病(IBD)是由肠黏膜免疫系统功能异常、肠道菌群紊乱等原因引起的一种慢性肠道疾病,具有遗传易感性。随着人口老龄化进程和人群平均寿命增加,IBD患者不断增加。而阿尔茨海默病(AD)是老年期最常见的痴呆类型。研究显示IBD与AD存在一定关联,二者的病理生理机制相似,均涉及免疫失衡、慢性炎症和肠道菌群紊乱等。该文就IBD与AD的共病现象及其可能的病理生理机制进行了综述,以期加强临床医师对这一现象的认识,为早期识别和更好地管理此类患者提供参考。

Inflammatory bowel disease(IBD)is a chronic gastrointestinal disorder resulting from genetic susceptibility,abnormal immune function in the intestinal mucosa,disruptions of gut microbiota,and other factors.With the population aging,the numbers of elderly patients with IBD and those with Alzheimer diseases(AD)are on the rise.Studies have demonstrated that there is a significant association between IBD and AD,as both conditions share similar pathophysiological mechanisms:immune imbalance,chronic inflammation and gut microbiota disruptions.This article reviews the comorbidity between IBD and AD and the common pathological mechanisms of these two conditions to provide reference for clinical management of these patients.