生命早期肠道菌群特点及其对过敏进程影响的研究进展

Research progress on the characteristics of gut microbiome in early life and its influence on atopic march

过敏性疾病又称变态反应性疾病,受遗传背景和环境因素的双重影响,各个年龄段均可发生。近年来,许多研究表明过敏性疾病与肠道菌群存在密切关系。本文将从生命早期肠道微生物的构成及其与过敏的关系、对过敏进程的作用机制以及肠道菌群定植对过敏进程的影响等方面进行阐述,以期提高对儿童过敏防治与肠道菌群关系的认知,为过敏性疾病的早期预防和早期干预提供新思路。

Allergic diseases are affected by both genetic background and environmental factors.In recent years,many studies have shown that allergic diseases are closely related to the gut microbiome.This article will elaborate on the composition of gut microbiome in early life and its relationship with allergies,the mechanism of action,and the influence of gut microbiome colonization on the atopic march,in order to improve the understanding of the relationship between allergy prevention or treatment and gut microbiome in children,and provide new ideas for the early prevention of allergic diseases and the early intervention of allergic processes.