One Health视角下细菌耐药产生传播影响驱动因素及其机制研究进展

Research progress on the driving factors and mechanisms of antimicrobial resistance production and spread from the perspective of One Health

细菌耐药对公共健康构成严重威胁,是全球共同面对的重大挑战之一。随着全球社会、经济、环境变化导致人群对抗生素的暴露机会及程度增加,加速了病原菌对抗生素耐药性的产生和传播,致使药物临床感染治疗效果减弱。本文基于One Health视角综述细菌耐药性产生传播的主要机制及其驱动因素,多层面探讨控制细菌耐药性的方法及策略,并对耐药研究及防控的前景进行了展望,旨在探索基于One Health的细菌耐药防控策略。

Antimicrobial resistance poses a serious threat to public health and is one of the major challenges worldwide.As global social,economic,and environmental changes lead to increased exposure of populations to antimicrobials,the antimicrobial resistance of pathogens has accelerated and resulted in weakened clinical infection treatment effects.This article reviews the main mechanisms and driving factors of the production and spread of antimicrobial resistance from the perspective of"One Health"and discusses methods and strategies for controlling antimicrobial resistance from multiple dimensions.It also looks forward to the prospects of research and prevention of drug resistance to explore antimicrobial resistance prevention and control strategies based on"One Health".