多模态合一鸡尾酒疗法在晚期恶性肿瘤治疗中的应用

Application of"multimodal cocktail therapy"in the treatment of advanced malignant tumors

晚期恶性肿瘤的治疗方式通常包括化疗、放疗、免疫治疗、靶向治疗等。然而,单一的治疗手段常常面临耐药性、不良反应大等问题,因此,亟需寻求新的治疗模式及方法。2015年,Siwen Hu-Lieskovan首次提出了“肿瘤鸡尾酒疗法”。鸡尾酒疗法是将三种及以上不同的治疗手段有机整合,从而发挥协同抗肿瘤作用。近年来,许多研究者也将鸡尾酒疗法应用于基础和临床研究,包括:联合化疗药、靶向药以及免疫药等,使药物之间优势互补;联合热疗、化疗与免疫治疗,通过热疗改善肿瘤免疫抑制微环境,激发宿主免疫应答,再联合抗程序性死亡受体1(aPD-1)药物等产生协同作用。研究结果都显示鸡尾酒疗法可提升中晚期恶性肿瘤的疗效,改善患者的预后。本文对鸡尾酒疗法这种全新的治疗模式的作用和影响进行综述,以便为更深入探索新组合方案治疗中晚期恶性肿瘤提供参考。

The treatment of advanced malignant tumors usually includes chemotherapy,radiotherapy,immunotherapy and targeted therapy,etc.However,a single treatment often faces problems such as drug resistance,toxicity and side effects.Consequently,it is urgent to seek new methods.In 2015,Siwen Hu-Lieskovan proposed"oncology cocktail therapy"firstly.Cocktail therapy is the integration of three or more different methods to exert a synergistic anti-tumor effect.In recent years,many researchers have applied cocktail therapy in basic and clinical researches.For example,the combination of chemotherapy drugs,targeted drugs and immunotherapy drugs makes the advantages of drugs complementary.The combination of hyperthermia,chemotherapy and immunotherapy can improve the tumor immunosuppressive microenvironment and stimulate immunity,and then combines with anti-programmed death receptor 1(aPD-1)drugs to produce synergistic effects.The results show that cocktail therapy can improve the efficacy and prognosis of advanced cancer patients.In this article,the role and impact of cocktail therapy were reviewed,aiming to provide reference for in-depth exploration of new combined treatments for advanced malignant tumors.