lncRNA和circRNA在三阴性乳腺癌放疗敏感性中的研究进展

Advances in lncRNA and circRNA in triple-negative breast cancer radiotherapy

乳腺癌是世界范围内最常见和最严重的肿瘤类型之一,目前其发病率已超过肺癌。三阴性乳腺癌(TNBC)是乳腺癌的一种特殊分子亚型,具有预后差、复发率高、侵袭转移快和死亡率高等特点。目前放疗在三阴性乳腺癌的治疗中起辅助作用,并正被研究用于新辅助治疗。由于放射抵抗的存在,放疗在TNBC患者的临床应用仍然具有挑战,如何提高三阴性乳腺癌细胞对放射线的敏感性是近年来研究的热点问题之一。随着全基因组和转录组测序技术的快速发展,越来越多的证据表明,长链非编码RNA(lncRNA)、环状RNA(circRNA)对TNBC的放射敏感性有重要调控作用。本文对近年来关于lncRNA和circRNA对TNBC放射敏感性影响的研究进行综述,旨在为提高临床TNBC放射治疗的疗效提供理论依据。

Breast cancer(BC)is one of the most common and severe malignant tumors worldwide.Currently,the prevalence of BC has surpassed that of lung cancer.Triple-negative breast cancer(TNBC)is a special subtype of breast cancer,charactered by poor prognosis,strong invasion,high recurrence rate,and low survival rate,etc.Currently,radiotherapy plays an adjuvant role in the treatment of TNBC and is being investigated in the neoadjuvant setting.Due to the radioresistance,clinical application of radiotherapy in TNBC patients remains challenging.How to improve the radiosensitivity is a hot topic in recent years.With the rapid development of whole-genome and transcriptome sequencing,increasing evidence suggests that long chain non-coding RNA(lncRNA)and circular RNA(circRNA)can play a significant function in regulating the radiosensitivity in TNBC.In this article,research progress in the role of lncRNA and circRNA in the radiosensitivity of TNBC was reviewed,aiming to provide a theoretical basis for elevating the clinical efficacy of radiotherapy in TNBC.