聚桂醇联合不同浓度平阳霉素介入治疗肢体低流速静脉畸形的疗效

Lauromacrogol combined with different concentrations of pingyangmycin for low-flow venous malformations of limbs:analysis of therapeutic effect

目的对比聚桂醇联合不同浓度平阳霉素治疗肢体低流速静脉畸形的疗效。方法纳入2021年1月1日至2022年6月1日西安儿童医院胸外科/肿瘤(血管瘤)介入中心收治的肢体低流速静脉畸形患儿83例,随机分为A组42例,B组41例。两组分别在介入下给予聚桂醇混合平阳霉素,A组平阳霉素配置为2 mg/mL,B组平阳霉素1 mg/mL,影像引导下缓慢注射于静脉畸形瘤腔内部,使药物充盈留置瘤腔内。比较两组患儿治疗效果、6个月内治疗次数及发生不良反应的情况。结果A、B两组患儿均成功给予介入硬化治疗。随访6个月时,A组患儿治疗有效率92.9%(39/42),B组患儿治疗有效率87.8%(36/41)。A组共行介入治疗88次,B组共行介入治疗137次,差异有统计学意义(χ^(2)=3.282,P=0.047)。A组10例患儿发生不良反应,B组8例患儿发生不良反应,差异无统计学意义(P=0.709)。结论较高浓度的平阳霉素与聚桂醇混合液与较低浓度的治疗效果和不良反应相仿,但较高浓度平阳霉素与聚桂醇混合液可降低患儿治疗次数。

Objective To compare the therapeutic effect of lauromacrogol combined with different concentrations of pingyangmycin in the treatment of low-flow venous malformations of limbs.Methods A total of 83 child patients with low-flow venous malformations of limb,who were admitted to the Xi'an Thoracic Surgery/Tumor(Hemangioma)Intervention Center of China between 1 January 2021 and 1 June 2022,were enrolled in this study.The child patients were randomly divided into group A(n=42)and group B(n=41).Under imaging guidance,lauromacrogol mixed together with pingyangmycin(2 mg/mL in group A,and 1 mg/mL in group B)was slowly injected into the cavity of venous malformations until the drug mixture filled the tumor cavity.The curative effect,number of treatments within 6 months,and the incidence of adverse reactions were compared between the two groups.Results Successful interventional sclerotherapy was accomplished in all the 83 child patients of both groups.During the follow-up period of 6 months,the effective rate in group A and group B was 92.9%(39/42)and 87.8%(36/41)respectively.A total of 88 interventional procedures were performed in group A and 137 interventional procedures in group B,the difference between the two groups was statistically significant(χ^(2)=3.282,P=0.047).Adverse reactions occurred in 10 child patients of group A and in 8 child patients of group B,the difference between the two groups was not statistically significant(P=0.709).Conclusion In treating low-flow venous malformations of limbs,the use of higher concentration pingyangmycin and lauromacrogol mixture has quite the same curative effect and incidence of adverse effects as the use of lower concentration pingyangmycin and lauromacrogol mixture,although the use of higher concentration pingyangmycin and lauromacrogol mixture can reduce the number of treatments in child patients.