3D打印生物工程骨支架的相关研究进展

Research progress in 3D printed bioengineered bone scaffolds

组织工程学支架在人体骨缺损的修复方面具有不可低估的作用,但常规方法尚未取得满意的临床效果;在骨组织工程中,制备高性能支架是研究的重点。该领域主要生产具有理想形状、结构、物理、化学和生物特征的骨组织工程支架,以提高支架生物性能和提升修复骨缺损的效果。3D打印技术在生物医学工程的许多行业广泛运用。3D打印技术通过定制形状和结构,有可能制备理想的骨组织工程支架,使其具有仿生宏观或微观结构、合理的机械性以及良好的细胞或组织相容性。本文简要综述了3D打印制备不同类型骨组织支架的研究进展,并介绍了3D打印设计和制造骨组织工程支架最新理念。

Tissue engineering scaffolds play promising role in the repair of human bone defects,despite of unsatisfactory clinical results by the conventional methods.In bone tissue engineering,the preparation of high-performance scaffolds is the focus of research.This field mainly produces bone tissue engineering scaffolds with ideal shape,structure,as well as physical,chemical and biological characteristics to improve the biological performance of scaffolds and improve the effect of repairing bone defects.3D printing technology is widely used in many industries of biomedical engineering.By customizing the shape and structure,3D printing technology has the potential to prepare ideal bone tissue engineering scaffolds with bionic macro or micro structure,reasonable mechanical properties,and good cell or tissue compatibili⁃ty.This paper briefly reviewed the research progress of different types of bone tissue scaffolds prepared by 3D printing,and introduced the latest idea of designing and manufacturing bone tissue engineering scaffolds by 3D printing.