依达拉奉右坎醇联合丁苯酞注射液治疗急性脑梗死有效性及对血管内皮功能、炎症-氧化应激影响

Effect of edaravone and dextranol combined with butylphthalide injection on vascular endothelial function and inflammatory oxidative stress in patients with acute cerebral infarction

目的探讨依达拉奉右坎醇联合丁苯酞注射液对急性脑梗死(ACI)有效性及对血管内皮功能、炎症-氧化应激影响。方法选取2021年2月-2022年4月我院收治的208例ACI患者,按照随机平行试验原则和随机数字表法均分为常规组、联合组,各104例。2组均给予常规治疗,在此基础上常规组给予丁苯酞注射液,联合组给予依达拉奉右坎醇+丁苯酞注射液。比较2组疗效、美国国立卫生研究院卒中量表(NIHSS)、Barthel指数(BI)、血管内皮功能[血管内皮生长因子(VEGF)、内皮素-(ET-1)、可溶性血管细胞黏附分子-1(sVCAM-1)、氧化型低密度脂蛋白(ox-LDL)]、炎症-氧化应激[基质金属蛋白酶-2(MMP-2)、MMP-9、同型半胱氨酸(Hcy)、谷胱甘肽过氧化物酶(GSH-Px)]、不良反应。结果(1)联合组总有效率86.54%高于常规组72.12%(P<0.05)。(2)与常规组相比,联合组治疗后NIHSS评分下降,BI评分上升(P<0.05)。(3)治疗后,联合组VEGF、ET-1、sVCAM-1、ox-LDL改善幅度大于常规组(P<0.05)。(4)联合组治疗后MMP-9、MMP-12、Hcy低于常规组,GSH-Px高于常规组(P<0.05)。(5)联合组不良反应发生率7.69%与常规组4.81%比较,差异无统计学意义(P>0.05)。结论依达拉奉右坎醇联合丁苯酞治疗ACI,能促进神经功能恢复,减轻炎症-氧化应激损伤,提高血管内皮功能,增强疗效,提高生活质量。

bjective To investigate the effect of edaravone and dextranol combined with butylphthalide injection on acute cerebral infarction(ACI),vascular endothelial function and inflammatory oxidative stress.Methods 208 ACI patients admitted to our hospital from February 2021 to April 2022 were selected and divided into routine group and combined group according to the principle of random parallel test and random number table method,with 104 patients in each group.Both groups were given routine treatment.On this basis,the routine group was given butylphthalide injection,and the combined group was given edaravone dextranol+butylphthalide injection.Compare the efficacy of the two groups,NIHSS,Barthel index(BI),vascular endothelial function[vascular endothelial growth factor(VECF),endothelin-(ET-1),soluble vascular cell adhesion molecule-1(sVCAM-1),oxidized low density lipoprotein(ox LDL)]Inflammation oxidative stress[matrix metalloproteinase-2(MMP-2),MMP-9,homocysteine(Hcy),glutathione peroxidase(CSH Px)],adverse reactions.Results The total effective rate of the combined group was 86.54%higher than that of the conventional group(72.12%,P<O.05)Compared with the conventional group,NIHSS score in the combined group decreased and BI score increased after treatment(P<0.05)After treatment,the improvement of VEGF,ET-1,sVCAM-1,ox LDL in the combined group was greater than that in the conventional group(P<0.05)After treatment,MMP-9,MMP-12 and Hcy in the combined group were lower than those in the conventional group,and CSH Px was higher than that in the conventional group(P<0.05)The incidence of adverse reactions in the combination group was 7.69%compared with 4.81%in the conventional group,with no significant difference(P>0.05).Conclusion Edaravone and dextranol combined with butylphthalide in the treatment of ACI can promote the recovery of neural function,reduce inflammation oxidative stress injury,improve vascular endothelial function,enhance the efficacy and improve the quality of life.