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人乳头瘤病毒16/18感染与膀胱癌组织cyclinD1、P53蛋白表达的相关性分析

Correlation Between Human Papilloma Virus 16/18 Infection and CyclinD1,P53 Protein in Bladder Cancer Tissues
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摘要 目的 分析人乳头瘤病毒(HPV)16/18感染与膀胱癌组织细胞周期蛋白D1(cyclinD1)、P53蛋白表达的相关性。方法 采集62例膀胱癌患者的癌组织和癌旁组织。采用免疫组化染色和半定量积分方法,检测HPV16/18、cyclinD1和P53蛋白在膀胱癌及癌旁组织中的表达水平,并分析其表达与膀胱癌临床病理特征的关系以及THPV16/18与cyclinD1、P53蛋白表达的相关性。结果 膀胱癌组织中,HPV16/18、cyclinD1和P53蛋白的阳性率高于癌旁组织(P<0.05);HPV16/18、cyclinD1和P53蛋白阳性率病理分级高、临床分级高、有远处转移的膀胱癌组织分别高于病理分级低、临床分级低、无远处转移的膀胱癌组织(P<0.05);HPV16/18阳性组cyclinD1和P53蛋白阳性率高于HPV16/18阴性组(P<0.05);膀胱癌组织中HPV16/18表达与cyclinD1表达无相关性(P>0.05),与P53蛋白表达呈正相关(P<0.05)。结论 HPV16/18、cyclinD1和P53蛋白均参与了膀胱癌的发生和发展,HPV16/18可以影响P53蛋白的表达,参与膀胱癌的进展。 Objective To analyze the correlation between human papilloma virus(HPV)16/18 infection and cyclin D1(cyclinD1),P53 protein in bladder cancer tissues.Methods The cancer tissues and para-cancerous tissues from 62 patients with bladder cancer were collected.The expression levels of HPV16/18,cyclinD1 and P53 protein in bladder cancer tissues and para-cancerous tissues were detected by immunohistochemical staining and semi-quantitative scoring method.The relationship between their expressions and clinicopathological characteristics of bladder cancer,and the correlation between THPV16/18 and cyclinD1,p53 protein were analyzed.Results The positive rates of HPV16/18,cyclinD1 and P53 protein in bladder cancer tissues were higher than those in para-cancerous tissues(P<0.05).In bladder cancer tissues,positive rates of HPV16/18,cyclinD1 and P53 protein in patients with high pathological grading,high clinical staging and distant metastasis were higher than those with low pathological grading,low clinical staging and distant non-metastasis(P<0.05).The positive rate of cyclinD1 and P53 protein in HPV16/18 positive group were higher than those in HPV16/18 negative group(P<0.05).In bladder cancer tissues,HPV16/18 was not correlated with cyclinD1(P>0.05),while positively correlated with P53 protein(P<0.05).Conclusion HPV16/18,cyclinD1 and P53 protein are all involved in the occurrence and development of bladder cancer.HPV16/18 can affect the expression of P53 protein and participate in the progression of bladder cancer.
作者 韩腾飞 李武学 胡楠 HAN Tengfei;LI Wuxue;HU Nan(Dengfeng People's Hospital,Dengfeng,452470)
出处 《实用癌症杂志》 2024年第7期1115-1118,共4页 The Practical Journal of Cancer
关键词 人乳头瘤病毒 膀胱癌 细胞周期蛋白D1 P53蛋白 Human papilloma virus Bladder cancer Cyclin D1 P53 protein
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  • 1王栋,苏泽轩,肖亮生,岑松,黄卫,王阳.尿脱落细胞HPV_(16/18)E_7基因表达对膀胱移行细胞癌诊断价值的研究[J].临床泌尿外科杂志,2006,21(6):455-457. 被引量:3
  • 2张燕.病案首页手术切口分类及愈合等级的界定标准[J].中国病案,2006,7(9):22-22. 被引量:20
  • 3Haris AW,Bodrug SE,Warnce BJ,et al.CyclinD1 as the putative bel I oncogene[J].Gurr Top Microbiol Immunol,1995; 194:347-353
  • 4Polyak K,Lee MH,Erdjunmentg-Bromage H,et al.Cloning of p27kip1,a cyclin-dependent kinase inhibitor and potential mediator of extracelluar antimitogenic signal[J].Cell,1994;78(1):59-61
  • 5Philip W,Hinds,Steven F,et al.Funtion of hunman CyclinD1 gene as an oncogene[J].Proc Natl Acad Sci USA,1994;91:704-713
  • 6Masuda M,Hirakawa N,Nakashima T,et al.CyclinD1 overpression in primary hypophargngeal carcinomas[J].Cancer,1996;73(3):390-395
  • 7Harvat BL,Seth P,Jetten AM.The role of p27kip1 in gama interferon -mediated growth arrest of mammary epithelial cells and related defects in mammary carcinoma cell[J].Oncogene,1997; 14:2111-2115
  • 8Craig C,Wersto R,Kim M,et al.A recombinant adenovirus expression p27kip1 induces cycle arrest and loss of cyclin-CDK activity in human breast cancer cell[J].Oncogene,1997; 14:2283-2289
  • 9Franke KH,Miklosi M,Goebell P,et al.Cyclin-dependent kinase inhibitor p27kip1 is expressed preferentially in early stages of Uro the lial carcinoma[J].Urology,2000;56:689-695
  • 10Sgambato A,Migaldi M,Faraglia B,et al.Loss of p27kip1 expression correlatres with tumor grade and with reduced disease-free suivival in primary superficial bladder cancers[J].Cancers,1999;59:3245-3250

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