基于生物标志物和微流控技术的脓毒症早期诊断研究进展

Research progress in early diagnosis of sepsis based on biomarkers and microfluidic technology

脓毒症已成为全球公共健康领域的一个重大难题。由于其初始体征和症状具有非特异性,且缺乏足够敏感或特异的诊断评分系统及生物标志物,患者往往未能接受及时诊断和治疗,死亡率极高。因此,早期识别脓毒症并进行及时干预尤为重要,新型的脓毒症相关分子和生物标志物值得进一步深入研究。本文综述脓毒症的主要诊断方法,包括临床评估、生物标志物及新兴的诊断技术,旨在为临床工作者提供全面的参考。

Sepsis has become a major problem in the global public health.Due to its initial signs and symptoms are non-specific and there is no sufficiently sensitive or specific diagnostic scoring systems and biomarkers,patients often fail to receive timely diagnosis and treatment.This leads to extremely high mortality.Therefore,early recognition of sepsis and timely intervention are particularly important.Novel sepsis-related molecules and biomarkers are also worthy of further research.This article will review the main diagnostic methods of sepsis in detail.These include clinical assessment,biomarkers and emerging diagnostic technologies.Our aim is to provide a comprehensive reference for clinical workers.