血清胱抑素C、尿微量白蛋白、中性粒细胞明胶酶相关脂质运载蛋白联合检测在早期肾损伤患者中应用价值

The Application Value of Combined Detection of Serum Cystatin C,Urine Micro Albumin,and Neutrophil Gelatinase Associated Lipid Transport Protein in Patients with Early Kidney Injury

目的:探究血清胱抑素C(CysC)、尿微量白蛋白(mAlb)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)联合诊断在早期肾损伤中应用效果。方法:将2022年1月—2024年1月在漳州市中医院诊治糖尿病患者80例,根据肾小球滤过率(GFR)水平分为早期肾损伤组(A组)38例、单纯糖尿病组(B组)42例,并选择同期体检健康人员38例纳入对照组(C组),检测所有患者血清CysC、NGAL、尿mAlb水平,分析其对早期肾损伤的诊断价值。结果:与C组比较,A组、B组CysC、mAlb、NGAL水平均升高,差异均有统计学意义(P<0.05);与B组比较,A组CysC、mAlb、NGAL水平均高,差异均有统计学意义(P<0.05)。CysC、mAlb、NGAL敏感度均低于联合诊断,差异均有统计学意义(P<0.05);CysC、mAlb、NGAL单独诊断特异度与联合诊断特异度差异均无统计学意义(P>0.05);CysC、mAlb、NGAL准确度均低于联合诊断,差异均有统计学意义(P<0.05)。结论:CysC、mAlb、NGAL水平在早期肾损伤患者中呈异常高表达,且联合诊断早期肾损伤有着较高效能,可对早期肾损伤进行较为准确的鉴别。

Objective:To explore the application effect of combined diagnosis of serum cystatin C(CysC),urinary micro albumin(mAlb),and neutrophil gelatinase associated lipid transport protein(NGAL)in early renal injury.Method:From January 2022 to January 2024,80 patients with diabetes were diagnosed and treated in Zhangzhou Hospital of Traditional Chinese Medicine.According to the level of glomerular filtration rate(GFR),they were divided into 38 cases of early renal injury group(group A)and 42 cases of simple diabetes group(group B).38 healthy people were selected to be included in the control group(group C).The serum CysC,NGAL and urine mAlb levels of all patients were detected,and their diagnostic value for early renal injury was analyzed.Result:Compared with group C,the levels of CysC,mAlb and NGAL in group A and group B were all elevated,the differences were statistically significant(P<0.05);compared with group B,the levels of CysC,mAlb and NGAL in group A were higher,the differences were statistically significant(P<0.05).The sensitivity of CysC,mAlb and NGAL were lower than that of combined diagnosis,the differences were statistically significant(P<0.05);the differences in diagnostic specificity between CysC,mAlb and NGAL alone and in combination were not statistically significant(P>0.05);the accuracy of CysC,mAlb and NGAL were lower than that of combined diagnosis,the differences were statistically significant(P<0.05).Conclusion:The levels of CysC,mAlb and NGAL are abnormally high in patients with early kidney injury,and the combined diagnosis of early kidney injury has high efficacy,which can accurately distinguish early kidney injury.