中老年人群膳食炎症指数与胆石症的关联研究

Association between dietary inflammatory index and gallstone disease among middle-aged and elderly population

目的 探讨中老年人群膳食炎症指数(DII)与胆石症患病的关联,为预防和控制胆石症提供依据。方法 收集上海女性健康队列和上海男性健康队列基线调查资料,主要包括人口学信息、胆石症患病情况和饮食行为等,选择其中与常见炎症生物标志物相关的29种食物参数,并结合摄入量数据计算DII。采用多因素logistic回归模型分析DII与胆石症患病的关联。结果 132 312人纳入分析,其中男性59 627人,年龄M (QR)为53.07 (9.73)岁,中学学历41 544人,占69.67%,胆石症4 463例,患病率为7.48%,DII为-6.46~5.59;女性72 685人,年龄M (QR)为50.27(9.05)岁,中学学历47 380人,占65.19%,胆石症8 090例,患病率为11.13%,DII为-6.44~4.93。多因素logistic回归分析结果显示,调整年龄、文化程度、收入水平、吸烟、饮酒、饮茶、体力活动和绝经情况(仅女性)等因素后,男性DII与胆石症患病风险存在统计学关联(OR=1.095,95%CI:1.002~1.196),在女性中两者无统计学关联(P>0.05)。结论 男性中老年人群DII升高可能与胆石症风险增加有关。

Objective To analyze the association between dietary inflammatory index(DII)and gallstone disease among middle-aged and elderly population,so as to provide the evidence for the prevention and control of gallstone disease.Methods Baseline survey data were collected from the Shanghai Women's Health Study(SWHS)and Shanghai Men's Health Study(SMHS),including demographic information,gallstone disease prevalence and dietary habits.DII was calculated using 29 kinds of food parameters associated with common inflammatory biomarkers and food intake data of residents.A multivariable logistic regression model was used to analyze the association between dietary inflammatory index and gallstone disease.Results A total of 132312 individuals were included in the analysis.There were 59627 males and 72685 females.Among males,the median age was 53.07(interquartile range,9.73)years,41544 cases(69.67%)had an educational level of middle school,4463 cases(7.48%)had gallstone disease,and DII was-6.46 to 5.59.Among females,the median age was 50.27(interquartile range,9.05)years,47380 cases(65.19%)had an educational level of middle school,8090 cases(11.13%)had gallstone disease,and DII was-6.44 to 4.93.Multivariable logistic regression analysis showed that after adjusting for age,educational level,income level,smoking,alcohol consumption,tea consumption,physical activity and menopausal status(only for females),DII(OR=1.095,95%CI:1.002-1.196)was associated with an increased risk of gallston disease among males,but no statistically association was found among females(P>0.05).Conclusion DII might be associated with an increased risk of gallstone disease among middle-aged and elderly population.