关于β-羟基-β-甲基丁酸钙(CaHMB)应用的科学共识

Scientific Consensus on Application of Calciumβ-hydroxy-β-methylbutyrate(CaHMB)

羟基-β-甲基丁酸钙(CaHMB)作为新食品原料,已在国内外多个国家获批,允许在特殊医学用途配方食品中使用,然而我国在该原料获批后十余年间尚未有相关特殊医学用途配方食品上市。相关行业、监管部门和消费者对应用CaHMB的健康作用、安全性、使用剂量等方面的认知尚有待形成共识。为进一步推动CaHMB应用,服务人群营养健康需求,本文通过文献分析与专题研讨形式,在综合分析国内外有关CaHMB研究与应用现状的基础上,结合科技界与产业界有关专家意见,形成关于应用CaHMB的科学共识,即:1)通过新食品原料CaHMB(HMB的钙盐形式)补充HMB,是促进肌肉蛋白合成和减缓肌肉蛋白分解的一个重要途径;2)补充CaHMB有利于纠正负氮平衡,有利于老年人群、多类患病人群(如肌肉衰减综合征、肿瘤等)的肌肉健康;3)CaHMB的安全性被广泛认可,适当提高其每日最大食用限量,将更好地助力目标人群健康获益和产业应用发展。建议:从政策层面积极引导和适当提高CaHMB每日食用限量,以满足人群营养健康需求;进一步加强对Ca HMB的科研创新,为更好地应用CaHMB以及相关政策制定提供科技支撑;推动CaHMB在食品产业,尤其在特殊医学用途配方食品中的应用,促进相关产业高质量发展。

Calcium β-hydroxy-β-methylbutyrate(CaHMB),as a new food raw material,has obtained approval in multiple countries,including China.In China,CaHMB is allowed to be used in foods for special medical purposes.However,despite being approved in China for over a decade,no products containing CaHMB have been introduced as foods for special medical purposes to the market.Thus,there is a need to form a consensus on the health benefits,safety,dosage and other aspects of CaHMB to facilitate its application in the relevant food industry,regulatory authorities and consumer understanding,thereby advancing its application to better address the nutritional and health needs of the publication.This article provided comprehensive analysis of the global research and application of CaHMB,engaging relevant academic and industrial experts to form the scientific consensus on the application of CaHMB via literature analysis and scientific discussions,as:1)CaHMB,as new food raw material and the calcium salt form of HMB,plays a crucial role to supplement HMB in promoting muscle protein synthesis and reducing muscle protein breakdown;2)CaHMB supplementation is beneficial to correct the negative nitrogen balance and improving muscle health in the elderly and people with various diseases(such as sarcopenia syndrome,oncology,etc.);3)The safety of CaHMB is widely recognized,and appropriate increase its maximal daily intake limit locally can better support target population to receive health benefits and promote industrial application development.Recommendations:At the policy level,proactive measures can guide the appropriate increase in the maximal daily intake limit of CaHMB to better address the nutritional and health needs of the population;further strengthen scientific research and innovation on CaHMB to provide scientific and technical evidence supporting its optimal application and related policy development;promote CaHMB application in food industry,especially in foods for special medical purposes,to further forest high-quality development of related industries.