长链非编码RNA HEIH在急性髓系白血病患者中的表达及临床意义

Expression and Clinical Significance of LncRNA HEIH in Patients with Acute Myeloid Leukemia

目的:探讨长链非编码RNA HEIH在急性髓系白血病患者中的表达情况及临床意义。方法:2019年1月至2020年12月就诊于蚌埠医学院附属第一医院的50例初诊AML住院患者(M3除外)纳入研究,以30例血液系统非恶性肿瘤患者作为对照。检测所有患者lnc RNA HEIH的相对表达量,分析AML患者的临床特征、基因突变情况、FAB分型、疗效、预后及总生存期(OS)等与lnc RNA HEIH表达水平的相关性。结果:AML患者的lnc RNA HEIH相对表达水平明显高于血液系统非恶性肿瘤患者(P<0.01)。在AML患者中,高白细胞计数、CEBPA和FLT3基因突变、疗效差、预后不良的患者往往有较高的lnc RNA HEIH表达水平,且lnc RNA HEIH高表达的患者生存期较短。结论:lncRNA HEIH在AML患者中显示出独特的分子生物学意义,或许可为AML的诊断、监测及靶向治疗提供新方案。

Objective:To investigate the expression and clinical significance of long noncoding RNA(lncRNA)HEIH in patients with acute myeloid leukemia(AML).Methods:50 newly diagnosed AML patients(except M3)admitted to the First Affiliated Hospital of Bengbu Medical College from January 2019 to December 2020 were included in the study,with 30 patients with non-hematological malignancies as controls.The relative expression level of lncRNA HEIH in all patients were detected,the correlation of clinical characteristics,gene mutations,FAB classification,efficacy,prognosis and overall survival(OS)of AML patients with the expression level of lncRNA HEIH were analyzed.Results:The expression level of lncRNA HEIH in AML patients was significantly higher than that in patients with non-hematological malignancies(P<0.01).Moreover,AML patients with high white blood cell count(WBC),CEBPA and FLT3 mutations,poor efficacy,and poor prognosis often showed higher expression of lncRNA HEIH,and patients with high lncRNA HEIH expression showed a shorter overall survival(OS).Conclusion:lncRNA HEIH shows an unique molecular biological significance in AML patients,which may provide a new approach for diagnosis,monitoring and targeted therapy of AML.