基于数据挖掘技术分析肾纤维化的中医病机与治法

Analysis of pathogenesis and treatment of renal fibrosis in traditional Chinese medicine based on data mining techniques

目的运用数据挖掘技术分析肾纤维化的中医病机与治法。方法检索中国知网、万方数据库、维普数据库中截止2021年11月的中药复方治疗肾纤维化的全部中文文献。应用SPSS20.0、SPSS Clementine 12.0和Liquorice软件进行数据分析。结果共纳入899篇文献,涉及412首中药方剂,284味中药,累积频率3331次。肾纤维化中医病机主要为脾肾亏虚、浊毒血瘀;主要治法为健脾补肾、活血化瘀、泄浊解毒。使用频率居前10位的中药依次为:黄芪、丹参、生大黄、当归、茯苓、川芎、山茱萸、生地黄、白术和山药。应用关联规则分析得出51个药对,32个药组,药物配伍以黄芪最多;核心中药共23味;核心处方为参芪地黄汤合抵挡汤加减。结论肾纤维化的中医病机与治法:本虚以脾肾亏虚为主,标实以血瘀、浊毒为主;其治法以益气健脾补肾、活血泄浊为主。

Objective To analyze pathogenesis and treatment of renal fibrosis in traditional Chinese medicine based on data mining techniques.Methods All the Chinese periodical literatures as of November 2021were retrieved on the treatment of renal fibrosis with traditional Chinese medicine formulas from the China National Knowledge Infrastructure(CNKI)database,Wanfang database,and VIP database.Analysis was performed by meana of SPSS 20.0,SPSS Clementine 12.0,and Liquorice softwares.Results A total of 899 literatures were included,involving 412 Chinese medical formulas with 284 Chinese medicines,and the cumulative frequency was 3331 times.The pathogenesis of renal fibrosis in traditional Chinese medicine was mainly deficiency of spleen and kidney,turbid toxicity and blood stasis,while the main treatment methods were strengthening spleen and kidney,promoting blood circulation and removing blood stasis,relieving turbidity and detoxification.The top 10 most frequently used traditional Chinese medicines were:Astragalus membranaceus,Salvia miltiorrhiza,raw rhubarb,Angelica sinensis,Poria cocos,Ligusticum wallichii,Cornus officinalis,raw Rehmannia,Atractylodes macrocephala,and Chinese yam.Association rule analysis disclosed 51 drug pairs and 32 drug groups,with Astragalus membranaceus being the most compatible drug.There were 23 core traditional Chinese medicines,and the core prescription was Shenqi Dihuang decoction and Didang decoction with modifications.Conclusion The pathogenesis and treatment of renal fibrosis in traditional Chinese medicine is as follows.The deficiency in origin was the deficiency of spleen and kidney,while the excess in superficiality was mainly blood stasis and turbid toxicity.The treatment mainly focused on tonifying qi,strengthening spleen and kidney,promoting blood circulation,and relieving turbidity.