乳酸/乳酸化修饰调控巨噬细胞参与牙周病发生的研究进展

Research Progress on Regulation of Macrophages Involvement in Periodontal Disease by Lactate/Lactation Modification

乳酸作为糖酵解的最终产物,在能量来源、信号分子和免疫调节方面具有重要的作用,同时也是炎症性疾病的标志物之一。乳酸化修饰是近年来新发现的一种以乳酸和赖氨酸残基为底物的蛋白质翻译后修饰方式,其与多种炎性疾病密切相关。牙周炎是一种由牙周致病菌引发的免疫炎症,宿主免疫反应引发牙周组织损伤是其重要病因。最新研究发现,牙周炎微环境中乳酸含量增加,导致乳酸化水平的上升,最终可通过影响巨噬细胞极化和促进成骨细胞分化来抑制炎症进展和促进组织修复。因此,本文对近年有关乳酸/乳酸化修饰调控巨噬细胞功能及在牙周炎等炎性疾病中的研究进展进行了总结,以期为牙周炎的研究及治疗提供参考。

Lactate,as the end product of glycolysis,plays an important role in terms of energy sources,signaling molecules,and immune adjustment.Lactylation(Kla)is a newly discovered method to translate proteins based on lactate and lithium acid residues that are closely associated with a variety of inflammatory diseases.Peritoneal pathogens are the main cause of periodontitis(PD),which is an immune inflammation caused by the host's immune response.According to recent research,the increase of lactate content in periodontitis microenvironment leads to the increase of lactylation level,which can eventually slow down the spread of inflammation and help tissue repair by changing the polarization of macrophages and promoting the differentiation of bone cell.Therefore,this paper reviews the research progress of lactate/lactylation in regulating macrophage function and inflammatory diseases such as periodontitis in recent years,so as to provide reference for follow-up research and treatment of periodontitis.