猪流行性腹泻病毒核衣壳蛋白的研究进展

Research Progress on Nucleocapsid Protein of Porcine Epidemic Diarrhea Virus

猪流行性腹泻病毒(PEDV)是猪流行性腹泻(PED)的病原,PEDV可导致猪的急性腹泻、脱水甚至死亡。PEDV最早在1971年被报道,如今,它已成为引起仔猪腹泻的最常见病原体之一,对我国养猪行业造成极大的经济损失。核衣壳(N)蛋白是PEDV主要的结构蛋白质之一。本文对PEDV N蛋白的核定位信号、生理功能、与宿主细胞互作和检测方法四个方面的研究进展综述,以期能对N蛋白的了解更够更加深入,并为PED防控提供参考作用。

Porcine epidemic diarrhea virus(PEDV)is the causative agent of porcine epidemic diarrhea(PED)characterized by acute diarrhea,dehydration and even death in pigs.PEDV was first reported in 1971.Today,PEDV has become one of the most common pathogens in piglet diarrhea cases,causing great economic losses to the pig industry.Nucleocapsid protein is one of the main structural proteins of PEDV.This paper summarized the research progress of the nuclear localization signal,physiological function,interaction with host cells and detection methods of PEDV N protein in order to provide a better understanding of N protein and a reference for PED prevention and control.