肺热咳喘口服液联合氯苯那敏对慢性咳嗽患儿症状、促炎/抗炎平衡及预后的影响

Effects of pulmonary fever and cough oral liquid combined with chlorpheniramine on symptoms,pro/anti-inflammatory balance and prognosis in children with chronic cough

目的:探讨肺热咳喘口服液联合氯苯那敏对慢性咳嗽患儿症状、促炎/抗炎平衡及预后的影响。方法:选取2017年6月至2019年12月漯河市中心医院收治的150例慢性咳嗽患儿,采用随机抽签法分为3组,每组50例。3组均采取常规治疗,A组采取肺热咳喘口服液+氯苯那敏,B组采取肺热咳喘口服液,C组采取氯苯那敏,均治疗10 d。观察对比3组临床疗效、不良反应、预后及治疗前后症状评分、呼吸生理指标[最大呼气中期流速(MMEF75/25)、第1秒用力呼气容积占预计值百分比(FEV1%)、最大呼气峰流速(PEF)]、促炎/抗炎因子(IL-5、IL-13、IFN-γ、IL-10)。结果:(1)A组治疗总有效率及PEF、MMEF75/25、FEV1%高于B组、C组,症状评分低于B组、C组(P<0.05),B组和C组治疗总有效率、症状评分及呼吸生理指标比较差异无统计学意义(P>0.05);(2)治疗后A组IL-5、IL-13水平低于B组、C组,IFN-γ、IL-10水平高于B组、C组,且B组IL-5、IL-13水平低于C组,IFN-γ、IL-10水平高于C组(P<0.05);(3)3组不良反应发生率及复发率比较差异无统计学意义(P>0.05)。结论:肺热咳喘口服液联合氯苯那敏治疗慢性咳嗽效果确切,有利于缓解咳嗽症状,改善呼吸功能,其机制可能与纠正促炎/抗炎失衡有关。

Objective:To investigate the effects of pulmonary fever and cough oral liquid combined with chlorpheniramine on symptoms,pro/anti-inflammatory balance and prognosis in children with chronic cough.Methods:A total of 150 children with chronic cough in Luohe Central Hospital from June 2017 to December 2019 were selected,and randomly divided into 3 groups,with 50 cases in each group.All 3 groups were treated with conventional treatment,pulmonary fever and cough oral solution+chlorpheniramine in group A,pulmonary fever and cough oral solution in group B,and chlorpheniramine in group C,all treated for 10 days.Clinical efficacy,adverse effects,prognosis and pre-and post-treatment symptom scores,respiratory physiological indexes[maximum mid-expiratory flow rate(MMEF75/25),1st second forceful expiratory volume as a percentage of expected value(FEV1%),maximum peak expiratory flow rate(PEF)],pro/anti-inflammatory factors(IL-5,IL-13,IFN-γ,IL-10)were observed in three groups.Results:①Total treatment efficiency and PEF,MMEF75/25,FEV1%in group A were higher than those in groups B and C,while symptom scores were lower than those in groups B and C(P<0.05),there was no statistically significant difference between the total treatment efficiency,symptom scores and respiratory physiological indexes in groups B and C(P>0.05);②After treatment,levels of IL-5 and IL-13 in group A were lower than those in groups B and C,while levels of IFN-γand IL-10 were higher than those in groups B and C.Moreover,levels of IL-5 and IL-13 in group B were lower than those in group C,while levels of IFN-γand IL-10 were higher than those in group C(P<0.05);③There was no statistically significant difference in the incidence of adverse reactions and recurrence rate between the three groups(P>0.05).Conclusion:Pulmonary fever and cough oral liquid combined with chlorpheniramine is effective in treating chronic cough,which is beneficial in relieving cough symptoms and improving respiratory function,and the mechanism may be related to correcting the pro-inflammatory/anti-inflammatory imbalance.