基于类器官的炎症性肠病免疫机制研究进展

Research progress on immune mechanism of inflammatory bowel disease based on organoid technology

炎症性肠病(IBD)是一种以肠道免疫稳态紊乱为特征的慢性特发性疾病,以克罗恩病(CD)和溃疡性结肠炎(UC)两种类型为主。其发病机制包含固有免疫和特异性免疫异常,广泛涉及肠黏膜屏障、免疫细胞、细胞因子至微生物稳态等。肠道3D类器官以包含所有肠上皮细胞类型为特征,其问世为体外模拟IBD免疫微环境提供了良好模型。本文基于类器官技术讨论IBD器官模型构建的方法,同时对类器官模型IBD免疫机制研究和免疫治疗的进展进行综述。

Inflammatory bowel disease(IBD),mainly containing Crohn's disease(CD)and ulcerative colitis(UC),is a kind of chronic idiopathic disease.The dysregulated mucosal immune response of IBD has been shown to be an important feature of disease progression.Its pathogenesis is characterized by the abnormal function of innate and specific immune associated with mucosal barrier,immune cells,cytokines and microbial homeostasis.Intestinal 3D organoids give rise to all types of cells of intestinal epithelium,providing a promising model for simulating the original immune microenvironment of IBD in vitro.After briefly introducing the method of constructing an organoid model for IBD,this article reviews the progress of immune mechanism and immunotherapy of IBD under the organoid model.