孕产妇孕早、中、晚期D-二聚体、凝血四项指标检验结果及临床意义分析

Analysis of the Test Results and Clinical Significance of Four Indicators of D-dimer and Blood Coagulation in Early,Middle and Late Pregnancy of Pregnant Women

目的分析孕产妇孕早、中、晚期D-二聚体、凝血四项指标检验结果及临床意义。方法选择分娩的247例孕产妇作为研究对象,统计入选产妇孕期并根据孕期分为孕早期组(67例)、孕中期组(81例)、孕晚期组(99例),纳入同期50例于院内体检的健康非妊娠女性作为对照组。比较四组D-二聚体、凝血四项指标[纤维蛋白原、凝血活酶时间(TT)、活化部分凝血酶时间(APTT)和凝血酶原时间(PT)]检验结果,分析孕产妇孕早、中、晚期D-二聚体、凝血四项指标检验结果及临床意义。结果孕晚期组D-二聚体、纤维蛋白原高于孕早期组、孕中期组,孕中期组D-二聚体、纤维蛋白原高于孕早期组,三组均高于对照组;孕晚期组TT、APTT、PT低于孕早期组、孕中期组,孕中期组TT、APTT、PT低于孕早期组,三组均低于对照组,差异有统计学意义(F=539.341、90.144、73.226、32.676、93.263,P_(均)<0.05)。Pearson相关性分析检验结果显示,D-二聚体、纤维蛋白原与孕期进展呈正相关(r=0.898、0.679,P_(均)<0.05);TT、APTT、PT与孕期进展呈负相关(r=0.649、0.497、0.693,P_(均)<0.05)。结论孕产妇孕早、中、晚期D-二聚体、凝血四项指标检验结果差异较大,定期对孕产妇进行检测,可以有效监测不同孕期的凝血功能状况,全面预警凝血功能障碍及中晚期妊娠妇女患上深静脉血栓的风险。

Objective To analyze the test results and clinical significance of D-dimer and blood coagulation in early,middle and late pregnancy.Methods 247 pregnant women were selected as the research subjects.The selected women were counted and divided into early pregnancy group(67 cases),mid pregnancy group(81 cases),and late pregnancy group(99 cases)based on their pregnancy period.50 healthy non pregnant women who underwent physical examination in the hospital during the same period were included as the control group.Compare the test results of four indexes of D-dimer and coagulation(fibrinogen,thromboplastin time(TT),activated partial thrombin time(APTT)and Prothrombin time)in four groups,and analyze the test results and clinical significance of four indexes of D-dimer and coagulation in early,middle and late pregnancy of pregnant women.Results D-dimer and fibrinogen in the third trimester group were higher than those in the first trimester group and the second trimester group,and D-dimer and fibrinogen in the second trimester group were higher than those in the first trimester group;The TT,APTT,and PT levels in the late pregnancy group were lower than those in the early and mid pregnancy groups.The TT,APTT,and PT levels in the mid pregnancy group were lower than those in the early pregnancy group,and all three groups were lower than the control group,with statistically significant differences(F=539.341,90.144,73.226,32.676,93.263,P<0.05).Pearson correlation analysis showed that D-dimer and fibrinogen were positively correlated with pregnancy progress(r=0.898,0.679,P<0.05);TT,APTT,PT were negatively correlated with pregnancy progression(r=0.649,0.497,0.693,all P<0.05).Conclusion The results of D-dimer and blood coagulation of pregnant women in early,middle and late pregnancy are quite different.Regular detection of pregnant women can effectively monitor the status of blood coagulation function in different pregnancy periods,and comprehensively warn of blood coagulation dysfunction and the risk of Deep vein thrombosis in middle and late pregnancy women.