血清CEA、CA125、AFP与慢性乙型肝炎病情的相关性

Correlation between Serum CEA,CA125 and AFP the Illnesscondition of Chronic Hepatitis B

目的探讨癌胚抗原(Serum carcinoembryonic antigen,CEA)、糖类抗原125(Carbohydrate antigen 125,CA125)、甲胎蛋白(Alpha Feto Protein,AFP)与慢性乙型肝炎(Chronic hepatitis B,CHB)病情的相关性。方法选取CHB患者78例,结合其病情严重程度分为轻度组(n=26)、中度组(n=26)及重度组(n=26),另选取同期健康体检者26例为对照组。所有人员均进行血清CEA、CA125、AFP水平检测,记录患者肝肾功能并分析终末期肝病模型(Model for End-stage Liver Disease,MELD)评分。分析血清CEA、CA125、AFP的阳性检出率,并对比各组之间的血清CEA、CA125、AFP水平及MELD评分,分析相关性。结果重度组血清CEA阳性检出率3.85%(1/26)、CA125阳性检出率7.69%(2/26)与中度组3.85%(1/26)、7.69%(2/26)、轻度组3.85%(1/26)、3.85%(1/26)比较差异无统计学意义(P>0.05);重度组AFP阳性检出率50.00%(13/26)较中度组26.92%(7/26)、轻度组19.23%(5/26)高(P<0.05);重度组、中度组、轻度组、对照组血清CEA、CA125水平对比差异无统计学意义(P>0.05);与对照组相比,重度组、中度组、轻度组AFP水平、MELD评分较高(P<0.05);Pearson分析显示,血清AFP水平(r=0.658,r=0.671)与慢性乙型肝炎患者MELD评分、病情程度呈正相关(P<0.05)。结论血清AFP水平会随着CHB患者病情加重而逐渐提高,且AFP水平与CHB的病情程度呈正相关。

Objective To investigate the correlation between serum carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),and alpha fetoprotein(AFP)and the illnesscondition of chronic hepatitis B(CHB).Methods 78 cases of patients with CHB in our hospital were selected,and they were divided into a mild group(n=26),a moderate group(n=26),and a severe group(n=26)based on the severity degree of the irillness condition.In addition,26 healthy individuals in the same period were selected as the control group.All personnel were tested for serum CEA,CA125,and AFP levels,the patients'liver and kidney functions were recorded,and the scores of Model for End Stage Liver Disease(MELD)were analyzed.The positive detection rates of serum CEA,CA125,and AFP were analyzed,and the levels of serum CEA,CA125,AFP,and as well as MELD scores among the groups were compared to analyze the correlation.Results There were no significant differences in the detectable rate of CEA positive 3.85%(1/26)and detectable rate of CA125positive7.69%(2/26)in the severe group compared with 3.85%(1/26)and 7.69%(2/26)in the moderate group and 3.85%(1/26)and 3.85%(1/26)in the mild group(P>0.05).The detectable rate of AFP positivein severe group was 50.00%(13/26),which was higher than 26.92%(7/26)in the moderate group and 19.23%(5/26)in the mild group(P<0.05);There were no significant differences in serum CEA and CA125 levels among the severegroup,the moderategroup,the mildgroup,and the control group(P>0.05);Compared with the control group,the AFP levels and MELD scores in the severegroup,the moderategroup,and the mild group were higher(P<0.05);Pearson analysis showed that serum AFP level(r=0.658,r=0.671)was positively correlated with MELD scores and severity degree of illnessconditionof chronic hepatitis B(P<0.05).Conclusion The serum AFP level will gradually increase with the aggravation of CHB patients,and there is a positive correlation between the AFP level and the severity of illnesscondition of CHB.