急性虫螨腈中毒研究综述

A Review of Acute Acanthamoeba Nematode Intoxication Studies

急性农药中毒作为生活性中毒的常见类型,其病死率居高不下,其中虫螨腈中毒尤为严重。虫螨腈作为一种高效、广谱的芳基吡咯类杀虫剂,在农业上广泛应用,它可通过消化道、皮肤、呼吸道及眼部吸收,其中消化道是最主要的吸收方式。一旦进入人体内,即可对细胞的正常代谢过程造成干扰,导致细胞能量代谢障碍,引发全高热反应,干扰神经信号传导,导致神经系统功能严重受损,对环境和人体健康的潜在危害不容忽视。本研究综述了急性虫螨腈中毒的中毒机制、临床表现、诊断策略、治疗策略、预后评估、急性中毒救治体系建设等方面的最新研究进展,旨在为临床医生提供全面的认识与防治策略。本文还探讨了建立和完善区域性中毒救治体系的必要性,以期提高虫螨腈高安全使用水平及救治成功率。

Acute pesticide poisoning is a common life poisoning with high mortality,especially chlorfenapyr poisoning.Chlorfenitrile,as a highly effective and broad-spectrum arylpyrrole insecticide,is widely used in agriculture.It can be absorbed through the digestive tract,skin,respiratory tract and eyes,among which the digestive tract is the most important absorption mode.Once it enters the human body,it can interfere with the normal metabolic process of cells,leading to cell energy metabolism disorders,triggering total hyperthermia response,interfering with nerve signal transmission,leading to serious damage to the function of the nervous system,and the potential harm to the environment and human health cannot be ignored.This study reviewed the mechanism,clinical manifestations,diagnostic strategy,treatment strategy,prognosis assessment,acute poisoning treatment system construction and other aspects of the latest research progress,aimed at providing clinicians with comprehensive understanding and prevention strategies.This paper also discusses the necessity of establishing and improving the regional poisoning treatment system in order to improve the safe use level of chlorfenapyr and the success rate of treatment.