摘要
Splicing of pre-RNA is a key step in regulating eukaryotic gene expression.Most human genes undergo alternative splicing(AS),where the splice sites in a single gene can be selectively paired to produce multiple isoforms,greatly expanding the functional diversity(Pan et al.,2008;Wang et al.,2008).The regulation of AS plays a critical role in many cellular activities,such as cell differentiation.Therefore,the dysregulation of AS can lead to a variety of diseases,including cancers(Scotti and Swanson,2016).
基金
supported by the National Key Research and Development Program of China(2021YFF0703702 to G.Z.
2021YFA1300503 and 2018YFA0107602 to Z.W.)
the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB38040100 to Z.W.and XDB38030100 to G.Z.)
the Starry Night Science Fund at Shanghai Institute for Advanced Study of Zhejiang University(SN-ZJU-SIAS-009 to Z.W.)。
