The interplay between the muscle and liver in the regulation of glucolipid metabolism

The liver,adipose tissue,and skeletal muscle work not only independently but also collaboratively to maintain glucose and lipid homeostasis under different nutritional and environmental conditions(da Silva Rosa et al.,2020).Dysfunctions of these active metabolic and endocrine tissues lead to a variety of metabolic,cardiovascular,and cerebrovascular disorders,including type 2 diabetes mellitus(T2DM),atherosclerosis,metabolic-associated fatty liver disease(MAFLD;also previously known as non-alcoholic fatty liver disease),and stroke(Wang et al.,2020).Here,we summarize the interaction between the liver and muscle in the regulation of glucolipid metabolism and discuss the key metabolic factors that mediate their crosstalk in the context of physiological(fasting and postprandial state)and pathological conditions(obesity,T2DM,and MAFLD).